KLF5 KLF transcription factor 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLF5provided by HGNC
Official Full Name: KLF transcription factor 5provided by HGNC
Primary source: HGNC:HGNC:6349
See related: Ensembl:ENSG00000102554 MIM:602903; AllianceGenome:HGNC:6349
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CKLF; IKLF; BTEB2
Summary: This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Expression: Broad expression in skin (RPKM 92.1), esophagus (RPKM 91.6) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q22.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (73054976..73077538)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (72276491..72299055)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (73629114..73651676)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KLF5 inhibition initiates epithelial-mesenchymal transition in non-transformed human squamous epithelial cells.
Title: KLF5 inhibition initiates epithelial-mesenchymal transition in non-transformed human squamous epithelial cells.
linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability.
Title: linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability.
Kruppel-like factor 5 regulates wound repair and the innate immune response in human airway epithelial cells.
Title: Krüppel-like factor 5 regulates wound repair and the innate immune response in human airway epithelial cells.
Downregulation of KLF5 by EBER1 via the ERK signaling pathway in EBV-positive nasopharyngeal carcinoma cells: implications for latent EBV infection.
Title: Downregulation of KLF5 by EBER1 via the ERK signaling pathway in EBV-positive nasopharyngeal carcinoma cells: implications for latent EBV infection.
KLF5 regulates actin remodeling to enhance the metastasis of nasopharyngeal carcinoma.
Title: KLF5 regulates actin remodeling to enhance the metastasis of nasopharyngeal carcinoma.
Abrogation of KLF5 sensitizes BRCA1-proficient pancreatic cancer to PARP inhibition.
Title: Abrogation of KLF5 sensitizes BRCA1-proficient pancreatic cancer to PARP inhibition.
KLF5 promotes the ossification process of ligamentum flavum by transcriptionally activating CX43.
Title: KLF5 promotes the ossification process of ligamentum flavum by transcriptionally activating CX43.
Ubiquitin specific peptidase 38 epigenetically regulates KLF transcription factor 5 to augment malignant progression of lung adenocarcinoma.
Title: Ubiquitin specific peptidase 38 epigenetically regulates KLF transcription factor 5 to augment malignant progression of lung adenocarcinoma.
Depression of LncRNA DANCR alleviates tubular injury in diabetic nephropathy by regulating KLF5 through sponge miR-214-5p.
Title: Depression of LncRNA DANCR alleviates tubular injury in diabetic nephropathy by regulating KLF5 through sponge miR-214-5p.
[Overexpression of tuftelin and KLF-5 and its clinicopathological features in hepatitis B virus-related hepatocellular carcinoma].
Title: [Overexpression of tuftelin and KLF-5 and its clinicopathological features in hepatitis B virus-related hepatocellular carcinoma].

Submit: New GeneRIF Correction See all GeneRIFs (217)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of Kruppel-like factor 5 (KLF5) in U-937 macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

116d19FWD (e-PCR)
- UniSTS:240645

257f24FWD (e-PCR)
- UniSTS:240678

RH91880 (e-PCR)
- UniSTS:92987

42o17FWD (e-PCR)
- UniSTS:240706

G67088 (e-PCR)
- UniSTS:178321

KLF5_2413 (e-PCR)
- UniSTS:280810

KLF5 (e-PCR)
- UniSTS:505340

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables MRF binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
involved_in intestinal epithelial cell development	IEA Inferred from Electronic Annotation more info
involved_in microvillus assembly	IEA Inferred from Electronic Annotation more info
involved_in myotube differentiation involved in skeletal muscle regeneration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by transcription factor localization	IEA Inferred from Electronic Annotation more info
involved_in regulation of microvillus assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in satellite cell activation involved in skeletal muscle regeneration	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle satellite cell differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Krueppel-like factor 5

Names: (intestinal Kruppel-like factor; BTE-binding protein 2; GC box binding protein 2; Kruppel like factor 5; Kruppel-like factor 5 (intestinal); basic transcription element binding protein 2; colon krueppel-like factor; colon kruppel-like factor; epididymis secretory sperm binding protein; intestinal-enriched krueppel-like factor; intestinal-enriched kruppel-like factor; transcription factor BTEB2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286818.2 → NP_001273747.1 Krueppel-like factor 5 isoform 2

See identical proteins and their annotated locations for NP_001273747.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as tKLF5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AF132818, AK131397, AK302280, BM982025

Consensus CDS

CCDS66562.1

UniProtKB/TrEMBL

B4E2I1

Related

ENSP00000440407.1, ENST00000539231.5

Conserved Domains (3) summary

COG5048
Location:268 → 342

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:287 → 306

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:328 → 353

zf-H2C2_2; Zinc-finger double domain
NM_001730.5 → NP_001721.2 Krueppel-like factor 5 isoform 1

See identical proteins and their annotated locations for NP_001721.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF132818, AK131397, BC007695, BC014302, BM982025

Consensus CDS

CCDS9448.1

UniProtKB/Swiss-Prot

A2TJX0, L0R3U5, L0R4T9, Q13887, Q9UHP8

UniProtKB/TrEMBL

A0A0A0N0M4, Q5T6X2

Related

ENSP00000366915.4, ENST00000377687.6

Conserved Domains (3) summary

COG5048
Location:359 → 433

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:378 → 397

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:433 → 455

zf-C2H2; Zinc finger, C2H2 type