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    Zfp932 zinc finger protein 932 [ Mus musculus (house mouse) ]

    Gene ID: 69504, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp932provided by MGI
    Official Full Name
    zinc finger protein 932provided by MGI
    Primary source
    MGI:MGI:1916754
    See related
    Ensembl:ENSMUSG00000066613 AllianceGenome:MGI:1916754
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf431; 2310001H12Rik
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin binding activity; and histone deacetylase binding activity. Involved in negative regulation of DNA-binding transcription factor activity and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and skeleton. Orthologous to human ZNF17 (zinc finger protein 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 7.3), frontal lobe adult (RPKM 6.3) and 22 other tissues See more
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    Genomic context

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    See Zfp932 in Genome Data Viewer
    Location:
    5 F; 5 53.29 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110144334..110160132)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (109996502..110012266)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9259 Neighboring gene predicted gene, 26808 Neighboring gene predicted gene, 57735 Neighboring gene predicted gene 15446 Neighboring gene STARR-seq mESC enhancer starr_13938 Neighboring gene STARR-seq mESC enhancer starr_13939 Neighboring gene predicted gene, 54334 Neighboring gene zinc finger protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZFP932 suppresses cellular Hedgehog response and Patched1 transcription. Huang GJ, et al. Vitam Horm, 2012. PMID 22391310
    2. A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription. He Z, et al. J Biol Chem, 2011 Mar 4. PMID 21177534, Free PMC Article
    3. TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2. Lv X, et al. Acta Pharm Sin B, 2023 Apr. PMID 37139431, Free PMC Article
    4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF431 directly represses Patched1 expression and likely functions to repress the hedgehog response in cells
      Title: A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of osteoblast differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 431

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374712.1 → NP_001361641.1  zinc finger protein 431 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123679
      Consensus CDS
      CCDS89966.1
      UniProtKB/TrEMBL
      D3Z1G5
      Related
      ENSMUSP00000119843.3, ENSMUST00000125213.9
      Conserved Domains (3) summary
      COG5048
      Location:51 → 454
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:101 → 121
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:449 → 473
      zf-H2C2_2; Zinc-finger double domain

    2. NM_145563.2 → NP_663538.2  zinc finger protein 431 isoform 1

      See identical proteins and their annotated locations for NP_663538.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC123679
      Consensus CDS
      CCDS59681.1
      UniProtKB/Swiss-Prot
      E9QAG8
      Related
      ENSMUSP00000108159.2, ENSMUST00000112540.8
      Conserved Domains (4) summary
      COG5048
      Location:84 → 487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:134 → 154
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:5 → 45
      KRAB; KRAB box
      pfam13465
      Location:482 → 506
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110144334..110160132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165474.1 → XP_036021367.1  zinc finger protein 431 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:38 → 433
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:42 → 62
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_036165473.1 → XP_036021366.1  zinc finger protein 431 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:38 → 433
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:42 → 62
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_036165470.1 → XP_036021363.1  zinc finger protein 431 isoform X2

      UniProtKB/TrEMBL
      D3Z1G5
      Conserved Domains (3) summary
      COG5048
      Location:51 → 454
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:101 → 121
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:449 → 473
      zf-H2C2_2; Zinc-finger double domain

    4. XM_017321093.2 → XP_017176582.1  zinc finger protein 431 isoform X2

      UniProtKB/TrEMBL
      D3Z1G5
      Conserved Domains (3) summary
      COG5048
      Location:51 → 454
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:101 → 121
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:449 → 473
      zf-H2C2_2; Zinc-finger double domain

    5. XM_017321092.2 → XP_017176581.1  zinc finger protein 431 isoform X1

      UniProtKB/TrEMBL
      A0AA74KT52
      Conserved Domains (4) summary
      COG5048
      Location:83 → 486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:133 → 153
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 44
      KRAB; KRAB box
      pfam13465
      Location:481 → 505
      zf-H2C2_2; Zinc-finger double domain

    6. XM_036165472.1 → XP_036021365.1  zinc finger protein 431 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:38 → 433
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:42 → 62
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_036165471.1 → XP_036021364.1  zinc finger protein 431 isoform X2

      UniProtKB/TrEMBL
      D3Z1G5
      Conserved Domains (3) summary
      COG5048
      Location:51 → 454
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:101 → 121
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:449 → 473
      zf-H2C2_2; Zinc-finger double domain

    8. XM_017321095.3 → XP_017176584.1  zinc finger protein 431 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:38 → 433
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:42 → 62
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9QAG8.1 GenPept UniProtKB/Swiss-Prot:E9QAG8

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