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    fhaB filamentous hemagglutinin/adhesin [ Bordetella pertussis ]

    Gene ID: 69601663, updated on 29-Mar-2024

    Summary

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    Gene symbol
    fhaB
    Gene description
    filamentous hemagglutinin/adhesin
    Locus tag
    CXD86_RS09095
    Gene type
    protein coding
    RefSeq status
    PIPELINE
    Organism
    Bordetella pertussis (strain: H640, nat-host: Homo sapiens)
    Lineage
    Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Bordetella
    Old locus tag
    CXD86_09050
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    Genomic context

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    NZ_CP025371.1Genomic Context describing neighboring genes Neighboring gene virulence factors two-component system sensor histidine kinase BvgS Neighboring gene virulence factors two-component system response regulator BvgA Neighboring gene protein FimA Neighboring gene molecular chaperone FimB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NZ_CP025371.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway. Clantin B, et al. Proc Natl Acad Sci U S A, 2004 Apr 20. PMID 15079085, Free PMC Article
    2. Cloning, partial sequence, expression, and antigenic analysis of the filamentous hemagglutinin gene of Bordetella pertussis. Delisse-Gathoye AM, et al. Infect Immun, 1990 Sep. PMID 1696934, Free PMC Article
    3. The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model. Holubova J, et al. PLoS Pathog, 2022 Apr. PMID 35395059, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model.
      Title: The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model.
    Submit: New GeneRIF Correction

    General protein information

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    Preferred Names
    filamentous hemagglutinin/adhesin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NZ_CP025371.1 Reference assembly

      Range
      1854427..1865199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_010930610.1 filamentous hemagglutinin/adhesin [Bordetella pertussis]

      See identical proteins and their annotated locations for WP_010930610.1

      Status: PIPELINE

      UniProtKB/Swiss-Prot
      P12255, Q45364
      UniProtKB/TrEMBL
      A0A381A265, Q45365, Q8VV99
      Conserved Domains (7) summary
      sd00046
      Location:1440 → 1457
      FHA_bHelix; FHA beta-helical repeat [structural motif]
      NF033176
      Location:290 → 789
      auto_AIDA-I; autotransporter adhesin AIDA-I
      NF033177
      Location:1217 → 1678
      auto_Ag43; autotransporter adhesin Ag43
      pfam05860
      Location:77 → 204
      Haemagg_act; haemagglutination activity domain
      pfam13018
      Location:1 → 23
      ESPR; Extended Signal Peptide of Type V secretion system
      pfam13332
      Location:2919 → 3085
      Fil_haemagg_2; Haemagluttinin repeat
      NF033839
      Location:3218 → 3473
      PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12255.4