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    Ppp1r35 protein phosphatase 1, regulatory subunit 35 [ Mus musculus (house mouse) ]

    Gene ID: 69871, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ppp1r35provided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 35provided by MGI
    Primary source
    MGI:MGI:1922853
    See related
    Ensembl:ENSMUSG00000029725 AllianceGenome:MGI:1922853
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010007H12Rik; 2010011D20Rik
    Summary
    Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Involved in notochord morphogenesis and positive regulation of cilium assembly. Predicted to be located in centrosome. Predicted to be active in centriole. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and hemolymphoid system. Orthologous to human PPP1R35 (protein phosphatase 1 regulatory subunit 35). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.8), thymus adult (RPKM 25.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp1r35 in Genome Data Viewer
    Location:
    5 G2; 5 76.7 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137777138..137778372)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137778904..137780110)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Tsc22 domain family, member 4 Neighboring gene predicted gene, 57848 Neighboring gene sperm acrosome developmental regulator Neighboring gene STARR-positive B cell enhancer ABC_E4797 Neighboring gene STARR-positive B cell enhancer ABC_E857 Neighboring gene STARR-positive B cell enhancer ABC_E1312 Neighboring gene STARR-positive B cell enhancer ABC_E4798 Neighboring gene methylphosphate capping enzyme Neighboring gene zinc finger, CW type with PWWP domain 1 Neighboring gene STARR-seq mESC enhancer starr_14656 Neighboring gene paired immunoglobin-like type 2 receptor alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development. Archambault D, et al. Dev Biol, 2020 Sep 1. PMID 32628936, Free PMC Article
    2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    3. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development.
      Title: Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in notochord morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of centriole elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of centriole elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of centriole elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 35
    Names
    UPF0683 protein C7orf47 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356989.1 → NP_001343918.1  protein phosphatase 1 regulatory subunit 35 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC125063
      Conserved Domains (1) summary
      pfam15503
      Location:107 → 158
      PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

    2. NM_027242.5 → NP_081518.1  protein phosphatase 1 regulatory subunit 35 isoform 1

      See identical proteins and their annotated locations for NP_081518.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC125063, AK008148
      Consensus CDS
      CCDS19777.1
      UniProtKB/Swiss-Prot
      Q9D8C8
      Related
      ENSMUSP00000031739.5, ENSMUST00000031739.6
      Conserved Domains (1) summary
      pfam15503
      Location:107 → 253
      PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137777138..137778372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254798.2 → XP_030110658.1  protein phosphatase 1 regulatory subunit 35 isoform X1

      Conserved Domains (1) summary
      pfam15503
      Location:107 → 207
      PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8C8.1 GenPept UniProtKB/Swiss-Prot:Q9D8C8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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