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    Gtf3c5 general transcription factor IIIC, polypeptide 5 [ Mus musculus (house mouse) ]

    Gene ID: 70239, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gtf3c5provided by MGI
    Official Full Name
    general transcription factor IIIC, polypeptide 5provided by MGI
    Primary source
    MGI:MGI:1917489
    See related
    Ensembl:ENSMUSG00000026816 AllianceGenome:MGI:1917489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TFIIIC63; TFiiiC2-63; 2700084A09Rik
    Summary
    Predicted to enable DNA binding activity and RNA polymerase III general transcription initiation factor activity. Predicted to contribute to RNA polymerase III type 1 promoter sequence-specific DNA binding activity and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human GTF3C5 (general transcription factor IIIC subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.0), limb E14.5 (RPKM 10.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gtf3c5 in Genome Data Viewer
    Location:
    2 A3; 2 19.38 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28456257..28473291, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28566245..28583279, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10087 Neighboring gene ral guanine nucleotide dissociation stimulator Neighboring gene VISTA enhancer mm337 Neighboring gene carboxyl ester lipase Neighboring gene STARR-positive B cell enhancer mm9_chr2:28440723-28441024 Neighboring gene predicted gene, 22675 Neighboring gene STARR-seq mESC enhancer starr_04029 Neighboring gene STARR-positive B cell enhancer ABC_E2606 Neighboring gene growth factor independent 1B Neighboring gene predicted gene, 52548

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Rajan S, et al. Physiol Genomics, 2012 Feb 1. PMID 22147266
    2. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    3. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase III general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase III promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIIC complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor 3C polypeptide 5
    Names
    TF3C-epsilon
    TFIIIC 63 kDa subunit
    TFIIICepsilon
    general transcription factor III polypeptide 5
    transcription factor IIIC 63 kDa subunit
    transcription factor IIIC subunit epsilon

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290484.1 → NP_001277413.1  general transcription factor 3C polypeptide 5 isoform a

      See identical proteins and their annotated locations for NP_001277413.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK147014, AL928994, AU016996, BQ179286
      Consensus CDS
      CCDS71012.1
      UniProtKB/Swiss-Prot
      Q8BLE3, Q8R0D0, Q8R2T8
      Related
      ENSMUSP00000109521.3, ENSMUST00000113889.9
      Conserved Domains (1) summary
      pfam09734
      Location:24 → 322
      Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

    2. NM_148928.3 → NP_683730.1  general transcription factor 3C polypeptide 5 isoform b

      See identical proteins and their annotated locations for NP_683730.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK147014, AU016996, BQ179286
      Consensus CDS
      CCDS15842.1
      UniProtKB/TrEMBL
      Q3UI98
      Related
      ENSMUSP00000028157.9, ENSMUST00000028157.9
      Conserved Domains (1) summary
      pfam09734
      Location:24 → 322
      Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      28456257..28473291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162560.1 → XP_036018453.1  general transcription factor 3C polypeptide 5 isoform X2

      Conserved Domains (1) summary
      pfam09734
      Location:43 → 197
      Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

    2. XM_011239177.4 → XP_011237479.1  general transcription factor 3C polypeptide 5 isoform X1

      Conserved Domains (1) summary
      pfam09734
      Location:43 → 197
      Tau95; RNA polymerase III transcription factor (TF)IIIC subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2T8.2 GenPept UniProtKB/Swiss-Prot:Q8R2T8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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