DIO2 iodothyronine deiodinase 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Gene symbol: DIO2
Gene description: iodothyronine deiodinase 2
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Summary: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. This protein is a selenoprotein containing the non-standard amino acid, selenocysteine (Sec), which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Unlike the other two members (DIO1 and DIO3) of this enzyme family, the mRNA for this gene contains an additional in-frame UGA codon that has been reported (in human) to function either as a Sec or a stop codon, resulting in two potential isoforms with one or two Sec residues; however, only the upstream Sec (conserved with the single Sec residue found at the active site in DIO1 and DIO3) was shown to be essential for enzyme activity (PMID:10403186). In addition, the lack of conservation of the protein extension past the second TGA codon suggests that the one-Sec containing isoform represents the canonical form. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2018]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 7

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	7	NC_041760.1 (142329727..142343735, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	7	NC_027899.1 (142709086..142723069, complement)

Chromosome 7 - NC_041760.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH68849 (e-PCR)
- UniSTS:13313

DIO2_8299 (e-PCR)
- UniSTS:468381

RH91531 (e-PCR)
- UniSTS:85999

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables thyroxine 5'-deiodinase activity	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: type II iodothyronine deiodinase

Names: deiodinase, iodothyronine type II

NP_001311436.2

EC 1.21.99.4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001324507.3 → NP_001311436.2 type II iodothyronine deiodinase

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the canonical, one-Sec containing isoform.

Source sequence(s)

QNVO02000421

UniProtKB/TrEMBL

G7MYX6

Conserved Domains (1) summary

pfam00837
Location:4 → 262

T4_deiodinase; Iodothyronine deiodinase

RNA

NR_159356.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an internal novel exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

QNVO02000421