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    Ppp6r2 protein phosphatase 6, regulatory subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 71474, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ppp6r2provided by MGI
    Official Full Name
    protein phosphatase 6, regulatory subunit 2provided by MGI
    Primary source
    MGI:MGI:1918724
    See related
    Ensembl:ENSMUSG00000036561 AllianceGenome:MGI:1918724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pp6r2; Saps2; 1110033O10Rik; 8430411H09Rik; B230107H12Rik
    Summary
    Predicted to enable protein phosphatase binding activity and protein phosphatase regulator activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human PPP6R2 (protein phosphatase 6 regulatory subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 17.5), adrenal adult (RPKM 14.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp6r2 in Genome Data Viewer
    Location:
    15 E3; 15 44.76 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89095654..89171218)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89211451..89287015)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene plexin B2 Neighboring gene microRNA 7118 Neighboring gene STARR-seq mESC enhancer starr_39459 Neighboring gene DENN domain containing 6B Neighboring gene microRNA 6958 Neighboring gene STARR-positive B cell enhancer ABC_E3151 Neighboring gene STARR-positive B cell enhancer ABC_E4146 Neighboring gene SET binding factor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:89140718-89140905 Neighboring gene STARR-positive B cell enhancer ABC_E5509 Neighboring gene microRNA 6959 Neighboring gene adrenomedullin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. Stefansson B, et al. J Biol Chem, 2006 Aug 11. PMID 16769727
    2. Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development. Hedlund E, et al. J Neurosci Res, 2004 Feb 1. PMID 14743444
    3. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152
    4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    5. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 6 regulatory subunit 2
    Names
    SAPS domain family, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356969.1 → NP_001343898.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC160538
      Consensus CDS
      CCDS27743.1
      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      UniProtKB/TrEMBL
      G3X9K4
      Related
      ENSMUSP00000154087.2, ENSMUST00000228284.2
      Conserved Domains (2) summary
      PHA03247
      Location:666 → 922
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    2. NM_001356970.1 → NP_001343899.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC160538
      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:526 → 782
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 394
      SAPS; SIT4 phosphatase-associated protein

    3. NM_026813.2 → NP_081089.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_081089.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest variant and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AC160538
      Consensus CDS
      CCDS27743.1
      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      UniProtKB/TrEMBL
      G3X9K4
      Conserved Domains (2) summary
      PHA03247
      Location:666 → 922
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    4. NM_027805.2 → NP_082081.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 2

      See identical proteins and their annotated locations for NP_082081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 2 which has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK084684
      UniProtKB/TrEMBL
      Q8C3X1
      Related
      ENSMUST00000226779.2
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 207
      SAPS; SIT4 phosphatase-associated protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      89095654..89171218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521405.3 → XP_006521468.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:694 → 950
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 562
      SAPS; SIT4 phosphatase-associated protein

    2. XM_036159591.1 → XP_036015484.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X18

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:512 → 768
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:26 → 353
      SAPS; SIT4 phosphatase-associated protein

    3. XM_006521398.3 → XP_006521461.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006521461.1

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:721 → 977
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 562
      SAPS; SIT4 phosphatase-associated protein

    4. XM_006521406.3 → XP_006521469.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      UniProtKB/TrEMBL
      A0A5F8MQ25
      Related
      ENSMUSP00000159040.2, ENSMUST00000238818.2
      Conserved Domains (2) summary
      PHA03247
      Location:693 → 949
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    5. XM_006521403.3 → XP_006521466.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:715 → 971
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 556
      SAPS; SIT4 phosphatase-associated protein

    6. XM_030248767.2 → XP_030104627.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X6

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:688 → 944
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 556
      SAPS; SIT4 phosphatase-associated protein

    7. XM_030248768.2 → XP_030104628.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X7

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:687 → 943
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 528
      SAPS; SIT4 phosphatase-associated protein

    8. XM_017316748.2 → XP_017172237.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:581 → 837
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 422
      SAPS; SIT4 phosphatase-associated protein

    9. XM_030248772.2 → XP_030104632.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:581 → 837
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 422
      SAPS; SIT4 phosphatase-associated protein

    10. XM_036159588.1 → XP_036015481.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X14

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:559 → 815
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:1 → 400
      SAPS; SIT4 phosphatase-associated protein

    11. XM_006521404.3 → XP_006521467.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X3

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:702 → 958
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:109 → 543
      SAPS; SIT4 phosphatase-associated protein

    12. XM_006521401.3 → XP_006521464.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006521464.1

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:721 → 977
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 562
      SAPS; SIT4 phosphatase-associated protein

    13. XM_030248766.2 → XP_030104626.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      UniProtKB/TrEMBL
      A0A5F8MQ25
      Conserved Domains (2) summary
      PHA03247
      Location:693 → 949
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    14. XM_017316749.3 → XP_017172238.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:581 → 837
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 422
      SAPS; SIT4 phosphatase-associated protein

    15. XM_036159586.1 → XP_036015479.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X9

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:674 → 930
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:109 → 515
      SAPS; SIT4 phosphatase-associated protein

    16. XM_036159587.1 → XP_036015480.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X12

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:647 → 903
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:109 → 515
      SAPS; SIT4 phosphatase-associated protein

    17. XM_006521400.3 → XP_006521463.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006521463.1

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:721 → 977
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 562
      SAPS; SIT4 phosphatase-associated protein

    18. XM_030248769.2 → XP_030104629.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X8

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:675 → 931
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:109 → 543
      SAPS; SIT4 phosphatase-associated protein

    19. XM_030248773.2 → XP_030104633.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:581 → 837
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 422
      SAPS; SIT4 phosphatase-associated protein

    20. XM_006521399.3 → XP_006521462.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006521462.1

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:721 → 977
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 562
      SAPS; SIT4 phosphatase-associated protein

    21. XM_030248765.2 → XP_030104625.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      UniProtKB/TrEMBL
      A0A5F8MQ25
      Conserved Domains (2) summary
      PHA03247
      Location:693 → 949
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    22. XM_030248774.2 → XP_030104634.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X13

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:581 → 837
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 422
      SAPS; SIT4 phosphatase-associated protein

    23. XM_030248770.2 → XP_030104630.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X11

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:660 → 916
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 528
      SAPS; SIT4 phosphatase-associated protein

    24. XM_017316750.2 → XP_017172239.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:553 → 809
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 394
      SAPS; SIT4 phosphatase-associated protein

    25. XM_030248775.2 → XP_030104635.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X15

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:554 → 810
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 422
      SAPS; SIT4 phosphatase-associated protein

    26. XM_036159589.1 → XP_036015482.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X16

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:553 → 809
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 394
      SAPS; SIT4 phosphatase-associated protein

    27. XM_030248776.2 → XP_030104636.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:526 → 782
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 394
      SAPS; SIT4 phosphatase-associated protein

    28. XM_030248779.2 → XP_030104639.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X19

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:432 → 691
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:26 → 276
      SAPS; SIT4 phosphatase-associated protein

    29. XM_030248778.2 → XP_030104638.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:526 → 782
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 394
      SAPS; SIT4 phosphatase-associated protein

    30. XM_030248777.2 → XP_030104637.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X17

      UniProtKB/TrEMBL
      Q6A018
      Conserved Domains (2) summary
      PHA03247
      Location:526 → 782
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:2 → 394
      SAPS; SIT4 phosphatase-associated protein

    31. XM_030248764.2 → XP_030104624.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      Conserved Domains (2) summary
      PHA03247
      Location:694 → 950
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 562
      SAPS; SIT4 phosphatase-associated protein

    32. XM_017316747.2 → XP_017172236.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X10

      UniProtKB/Swiss-Prot
      Q8R3Q2, Q9CXB7
      UniProtKB/TrEMBL
      G3X9K4
      Conserved Domains (2) summary
      PHA03247
      Location:666 → 922
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:128 → 534
      SAPS; SIT4 phosphatase-associated protein

    33. XM_030248780.1 → XP_030104640.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X21

      UniProtKB/TrEMBL
      A4FU84
      Conserved Domains (2) summary
      PHA03247
      Location:277 → 536
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:36 → 121
      SAPS; SIT4 phosphatase-associated protein

    34. XM_011245729.1 → XP_011244031.1  serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X20

      UniProtKB/TrEMBL
      A4FU84
      Conserved Domains (2) summary
      PHA03247
      Location:341 → 600
      PHA03247; large tegument protein UL36; Provisional
      pfam04499
      Location:1 → 185
      SAPS; SIT4 phosphatase-associated protein

    RNA

    1. XR_004938872.1 RNA Sequence

    2. XR_003951439.2 RNA Sequence

    3. XR_003951441.2 RNA Sequence

    4. XR_384046.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3Q2.1 GenPept UniProtKB/Swiss-Prot:Q8R3Q2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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