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    CRISP2 cysteine rich secretory protein 2 [ Homo sapiens (human) ]

    Gene ID: 7180, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CRISP2provided by HGNC
    Official Full Name
    cysteine rich secretory protein 2provided by HGNC
    Primary source
    HGNC:HGNC:12024
    See related
    Ensembl:ENSG00000124490 MIM:187430; AllianceGenome:HGNC:12024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT36; TPX1; TSP1; GAPDL5; CRISP-2
    Summary
    Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis (RPKM 156.0) See more
    Orthologs
    mouse all
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    Genomic context

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    See CRISP2 in Genome Data Viewer
    Location:
    6p12.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (49676652..49714220, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (49518797..49556206, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49660072..49681256, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6456 Neighboring gene cytochrome P450 family 2 subfamily AC member 1, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr6:49553494-49553995 Neighboring gene MPRA-validated peak5837 silencer Neighboring gene Rh associated glycoprotein Neighboring gene GATA motif-containing MPRA enhancer 217 Neighboring gene Sharpr-MPRA regulatory region 4614 Neighboring gene MPRA-validated peak5838 silencer Neighboring gene MPRA-validated peak5839 silencer Neighboring gene cysteine rich secretory protein 3 Neighboring gene phosphoglycerate kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human testicular protein TPX1/CRISP-2: localization in spermatozoa, fate after capacitation and relevance for gamete interaction. Busso D, et al. Mol Hum Reprod, 2005 Apr. PMID 15734896
    2. Human testis specific protein 1 expression in human spermatogenesis and involvement in the pathogenesis of male infertility. Du Y, et al. Fertil Steril, 2006 Jun. PMID 16759931
    3. Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian men. Jamsai D, et al. Hum Reprod, 2008 Sep. PMID 18550510
    4. [Expressions of cysteine-rich secretory protein 2 in asthenospermia]. Jing XW, et al. Zhonghua Nan Ke Xue, 2011 Mar. PMID 21485539
    5. Human sperm CRISP2 is released from the acrosome during the acrosome reaction and re-associates at the equatorial segment. Nimlamool W, et al. Mol Reprod Dev, 2013 Jun. PMID 23661501

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA methylation profiling identifies epigenetic differences between early versus late stages of diabetic chronic kidney disease.
      Title: DNA methylation profiling identifies epigenetic differences between early versus late stages of diabetic chronic kidney disease.
    2. CRISP2, CATSPER1 and PATE1 Expression in Human Asthenozoospermic Semen.
      Title: CRISP2, CATSPER1 and PATE1 Expression in Human Asthenozoospermic Semen.
    3. Discovery and validation of novel biomarkers for detection of cervical cancer.
      Title: Discovery and validation of novel biomarkers for detection of cervical cancer.
    4. The integrated network analysis identified BRCA1 and CRISP2 differentially methylated regions (DMR) as the most central disease-associated DNA methylation biomarkers. Moreover, methylation changes at BRCA1 and CRISP2 specific CpG sites were consistently associated with subclinical atherosclerosis measures.
      Title: Identification of differentially methylated BRCA1 and CRISP2 DNA regions as blood surrogate markers for cardiovascular disease.
    5. low expression of CRISP2 protein rather than its mRNA was observed in the ejaculated spermatozoa from asthenoteratozoospermic patients as compared with normozoospermic males
      Title: MicroRNA-27a-mediated repression of cysteine-rich secretory protein 2 translation in asthenoteratozoospermic patients.
    6. Results identified CRISP2 as a potential binding protein of PSP94 from human sperm.
      Title: Identification of CRISP2 from human sperm as PSP94-binding protein and generation of CRISP2-specific anti-peptide antibodies.
    7. Crisp2 genetic defects in sperm from humans and mice result in male infertility.
      Title: Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: implications for fertility disorders.
    8. Preliminary insight into the mechanism leading to the reduced CRISP2 expression in asthenozoospermia, offering a potential therapeutic target for treating male infertility or for male contraception.
      Title: The expression of cysteine-rich secretory protein 2 (CRISP2) and its specific regulator miR-27b in the spermatozoa of patients with asthenozoospermia.
    9. Study shows the re-association of sperm acrosomal CRISP2 at the EqS during the acrosome reaction. Data showed that F-actin is not involved in the relocalization of CRISP2. Found that basic,but not acidic, conditions can solubilize CRISP2 from sperm cells.
      Title: Human sperm CRISP2 is released from the acrosome during the acrosome reaction and re-associates at the equatorial segment.
    10. CRISP2 rescues the phenotype of yeast mutants lacking Pry function and purified CRISP2 binds cholesterol in vitro, indicating that lipid binding is a conserved function of the CAP superfamily proteins.
      Title: Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111136

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cysteine-rich secretory protein 2
    Names
    cancer/testis antigen 36
    glyceraldehyde-3-phosphate dehydrogenase-like 5
    testicular tissue protein Li 43
    testis specific protein 1 (probe H4-1 p3-1)
    testis-specific protein TPX-1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142407.3 → NP_001135879.1  cysteine-rich secretory protein 2 precursor

      See identical proteins and their annotated locations for NP_001135879.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BC107707, DB524518
      Consensus CDS
      CCDS4928.1
      UniProtKB/Swiss-Prot
      A8K8M0, P16562, Q53FF2, Q5U8Z9, Q7Z7B2
      UniProtKB/TrEMBL
      A0A024RD74
      Conserved Domains (2) summary
      cd05383
      Location:35 → 172
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
      pfam08562
      Location:189 → 243
      Crisp; Crisp

    2. NM_001142408.3 → NP_001135880.1  cysteine-rich secretory protein 2 precursor

      See identical proteins and their annotated locations for NP_001135880.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BC022011
      Consensus CDS
      CCDS4928.1
      UniProtKB/Swiss-Prot
      A8K8M0, P16562, Q53FF2, Q5U8Z9, Q7Z7B2
      UniProtKB/TrEMBL
      A0A024RD74
      Conserved Domains (2) summary
      cd05383
      Location:35 → 172
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
      pfam08562
      Location:189 → 243
      Crisp; Crisp

    3. NM_001142417.3 → NP_001135889.1  cysteine-rich secretory protein 2 precursor

      See identical proteins and their annotated locations for NP_001135889.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      DB459032, DB524518, M25532
      Consensus CDS
      CCDS4928.1
      UniProtKB/Swiss-Prot
      A8K8M0, P16562, Q53FF2, Q5U8Z9, Q7Z7B2
      UniProtKB/TrEMBL
      A0A024RD74
      Conserved Domains (2) summary
      cd05383
      Location:35 → 172
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
      pfam08562
      Location:189 → 243
      Crisp; Crisp

    4. NM_001142435.3 → NP_001135907.1  cysteine-rich secretory protein 2 precursor

      See identical proteins and their annotated locations for NP_001135907.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BI831679, BM552843, DB445739, DB524518
      Consensus CDS
      CCDS4928.1
      UniProtKB/Swiss-Prot
      A8K8M0, P16562, Q53FF2, Q5U8Z9, Q7Z7B2
      UniProtKB/TrEMBL
      A0A024RD74
      Conserved Domains (2) summary
      cd05383
      Location:35 → 172
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
      pfam08562
      Location:189 → 243
      Crisp; Crisp

    5. NM_001261822.2 → NP_001248751.1  cysteine-rich secretory protein 2 precursor

      See identical proteins and their annotated locations for NP_001248751.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BI562149, BP369378, BP369727, DB524518
      Consensus CDS
      CCDS4928.1
      UniProtKB/Swiss-Prot
      A8K8M0, P16562, Q53FF2, Q5U8Z9, Q7Z7B2
      UniProtKB/TrEMBL
      A0A024RD74
      Related
      ENSP00000484609.1, ENST00000616725.4
      Conserved Domains (2) summary
      cd05383
      Location:35 → 172
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
      pfam08562
      Location:189 → 243
      Crisp; Crisp

    6. NM_003296.4 → NP_003287.1  cysteine-rich secretory protein 2 precursor

      See identical proteins and their annotated locations for NP_003287.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
      Source sequence(s)
      AY773479, DB524518
      Consensus CDS
      CCDS4928.1
      UniProtKB/Swiss-Prot
      A8K8M0, P16562, Q53FF2, Q5U8Z9, Q7Z7B2
      UniProtKB/TrEMBL
      A0A024RD74
      Related
      ENSP00000339155.4, ENST00000339139.5
      Conserved Domains (2) summary
      cd05383
      Location:35 → 172
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
      pfam08562
      Location:189 → 243
      Crisp; Crisp

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      49676652..49714220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514843.4 → XP_011513145.1  cysteine-rich secretory protein 2 isoform X2

      Conserved Domains (1) summary
      cd05383
      Location:35 → 172
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...

    2. XM_011514841.2 → XP_011513143.1  cysteine-rich secretory protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011513143.1

      UniProtKB/Swiss-Prot
      P16562
      Conserved Domains (2) summary
      cd05383
      Location:35 → 172
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
      pfam08562
      Location:224 → 278
      Crisp; Crisp

    3. XM_005249349.2 → XP_005249406.1  cysteine-rich secretory protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005249406.1

      UniProtKB/Swiss-Prot
      P16562
      Related
      ENSP00000482890.1, ENST00000618917.4
      Conserved Domains (2) summary
      cd05383
      Location:35 → 172
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
      pfam08562
      Location:224 → 278
      Crisp; Crisp

    4. XM_005249356.2 → XP_005249413.1  cysteine-rich secretory protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005249413.1

      UniProtKB/Swiss-Prot
      P16562
      Conserved Domains (2) summary
      cd05383
      Location:35 → 172
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
      pfam08562
      Location:224 → 278
      Crisp; Crisp

    5. XM_005249351.4 → XP_005249408.1  cysteine-rich secretory protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005249408.1

      UniProtKB/Swiss-Prot
      P16562
      Conserved Domains (2) summary
      cd05383
      Location:35 → 172
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
      pfam08562
      Location:224 → 278
      Crisp; Crisp

    6. XM_005249353.5 → XP_005249410.1  cysteine-rich secretory protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005249410.1

      UniProtKB/Swiss-Prot
      P16562
      Conserved Domains (2) summary
      cd05383
      Location:35 → 172
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
      pfam08562
      Location:224 → 278
      Crisp; Crisp

    7. XM_047419293.1 → XP_047275249.1  cysteine-rich secretory protein 2 isoform X4

    8. XM_047419292.1 → XP_047275248.1  cysteine-rich secretory protein 2 isoform X3

    RNA

    1. XR_926302.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      49518797..49556206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356305.1 → XP_054212280.1  cysteine-rich secretory protein 2 isoform X2

    2. XM_054356304.1 → XP_054212279.1  cysteine-rich secretory protein 2 isoform X1

    3. XM_054356302.1 → XP_054212277.1  cysteine-rich secretory protein 2 isoform X1

    4. XM_054356301.1 → XP_054212276.1  cysteine-rich secretory protein 2 isoform X1

    5. XM_054356303.1 → XP_054212278.1  cysteine-rich secretory protein 2 isoform X1

    6. XM_054356300.1 → XP_054212275.1  cysteine-rich secretory protein 2 isoform X1

    7. XM_054356307.1 → XP_054212282.1  cysteine-rich secretory protein 2 isoform X4

    8. XM_054356306.1 → XP_054212281.1  cysteine-rich secretory protein 2 isoform X3

    RNA

    1. XR_008487433.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16562.1 GenPept UniProtKB/Swiss-Prot:P16562

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