Mtfr2 mitochondrial fission regulator 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtfr2provided by MGI
Official Full Name: mitochondrial fission regulator 2provided by MGI
Primary source: MGI:MGI:1919054
See related: Ensembl:ENSMUSG00000019992 AllianceGenome:MGI:1919054
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dufd1; Fam54a; 2610016C23Rik; 4933412C16Rik
Summary: Involved in aerobic respiration and mitochondrial fission. Located in mitochondrion. Is expressed in several structures, including heart; liver; lung; spleen; and testis. Orthologous to human MTFR2 (mitochondrial fission regulator 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E14 (RPKM 5.4), liver E14.5 (RPKM 5.1) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A3; 10 9.75 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (20223491..20237415)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (20344653..20361669)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dysregulation of MTFR2, ATP5IF1 and BAK1 in Sertoli cells relates to idiopathic non-obstructive azoospermia via inhibiting mitochondrial fission and inducing mitochondrial dysfunctiondagger.
Title: Dysregulation of MTFR2, ATP5IF1 and BAK1 in Sertoli cells relates to idiopathic non-obstructive azoospermia via inhibiting mitochondrial fission and inducing mitochondrial dysfunction†.
The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration and may affect male fertility.
Title: The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IBA Inferred from Biological aspect of Ancestor more info
involved_in aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fission	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrion organization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitochondrial fission regulator 2

Names: DUF729 domain containing 1; DUF729 domain-containing protein 1; family with sequence similarity 54, member A; protein FAM54A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.