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    Ccpg1 cell cycle progression 1 [ Mus musculus (house mouse) ]

    Gene ID: 72278, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ccpg1provided by MGI
    Official Full Name
    cell cycle progression 1provided by MGI
    Primary source
    MGI:MGI:1196419
    See related
    Ensembl:ENSMUSG00000034563 AllianceGenome:MGI:1196419
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CPR8; D9Ertd392e; 1700030B06Rik; 1810073J13Rik; 9430028F23Rik
    Summary
    Acts upstream of or within positive regulation of transcription by RNA polymerase II and regulation of Rho guanyl-nucleotide exchange factor activity. Located in membrane. Is expressed in cranial ganglion; dorsal root ganglion; sensory organ; and skeleton. Orthologous to human CCPG1 (cell cycle progression 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 12.0), frontal lobe adult (RPKM 11.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccpg1 in Genome Data Viewer
    Location:
    9 D; 9 40.08 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (72892692..72923622)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (72985402..73016340)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 4 Neighboring gene predicted gene, 23567 Neighboring gene STARR-positive B cell enhancer ABC_E3843 Neighboring gene piercer of microtubule wall 2 Neighboring gene STARR-seq mESC enhancer starr_24620 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class B Neighboring gene Pigb opposite strand 1 Neighboring gene RAB27A, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_24625 Neighboring gene STARR-seq mESC enhancer starr_24627

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic Reticulum Selective Autophagy Alleviates Anthracycline-Induced Cardiotoxicity. Nakagama S, et al. JACC CardioOncol, 2023 Oct. PMID 37969644, Free PMC Article
    2. CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis. Smith MD, et al. Dev Cell, 2018 Jan 22. PMID 29290589, Free PMC Article
    3. A biphasic pattern of gene expression during mouse retina development. Zhang SS, et al. BMC Dev Biol, 2006 Oct 17. PMID 17044933, Free PMC Article
    4. Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs. Kostenko EV, et al. Mol Cell Biol, 2006 Dec. PMID 17000758, Free PMC Article
    5. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. Yang Y, et al. EMBO J, 2022 Jul 18. PMID 35670107, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of Rho guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell cycle progression protein 1
    Names
    cell cycle progression 8 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114328.2 → NP_001107800.1  cell cycle progression protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001107800.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate exon in the 5' coding region and includes a 3' terminal exon that extends past a splice site that is used in variant 6. It encodes isoform 1, which has a distinct C-terminus and is shorter, compared to isoform 6.
      Source sequence(s)
      AK032645, BC082602, CN721780
      Consensus CDS
      CCDS52855.1
      UniProtKB/Swiss-Prot
      Q05BJ9, Q640L3, Q8C692, Q922W9
      Related
      ENSMUSP00000122966.2, ENSMUST00000150826.9
      Conserved Domains (1) summary
      pfam10577
      Location:133 → 218
      UPF0560; uncharacterized protein family UPF0560

    2. NM_001286544.1 → NP_001273473.1  cell cycle progression protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001273473.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, compared to variant 6. It encodes a shorter isoform (3), compared to isoform 6.
      Source sequence(s)
      BC043049, CN721780
      Consensus CDS
      CCDS72278.1
      UniProtKB/Swiss-Prot
      Q640L3
      Related
      ENSMUSP00000082458.5, ENSMUST00000085350.11
      Conserved Domains (1) summary
      pfam10577
      Location:133 → 218
      UPF0560; uncharacterized protein family UPF0560

    3. NM_001286545.1 → NP_001273474.1  cell cycle progression protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001273474.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 5' coding region and uses an alternate 3' structure, compared to variant 6. It encodes isoform 4, which has a distinct C-terminus and is shorter, compared to isoform 6.
      Source sequence(s)
      AC158997, AK134675, BC037183, BC043049, CN721780
      Consensus CDS
      CCDS72277.1
      UniProtKB/TrEMBL
      D3Z7R9
      Related
      ENSMUSP00000116976.2, ENSMUST00000140675.8
      Conserved Domains (1) summary
      pfam10577
      Location:133 → 218
      UPF0560; uncharacterized protein family UPF0560

    4. NM_001286546.1 → NP_001273475.1  cell cycle progression protein 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon in the 5' coding region, uses an alternate internal splice site and includes a 3' terminal exon that extends past a splice site that is used in variant 6. It encodes isoform 5, which has a distinct C-terminus and is shorter, compared to isoform 6.
      Source sequence(s)
      AK032645, BC082602, CN721780
      UniProtKB/Swiss-Prot
      Q640L3
      Conserved Domains (2) summary
      COG1196
      Location:186 → 445
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15662
      Location:32 → 116
      SPATA3; Spermatogenesis-associated protein 3 family

    5. NM_001359295.1 → NP_001346224.1  cell cycle progression protein 1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) represents the longest transcript and encodes the longest isoform (6).
      Source sequence(s)
      AC158997, BC043049
      Conserved Domains (2) summary
      COG1196
      Location:318 → 577
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07267
      Location:90 → 242
      Nucleo_P87; Nucleopolyhedrovirus capsid protein P87

    6. NM_001359296.1 → NP_001346225.1  cell cycle progression protein 1 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 6. It encodes isoform 7, which has a distinct C-terminus and is shorter, compared to isoform 6.
      Source sequence(s)
      AC158997, BC043049
      Conserved Domains (2) summary
      pfam07267
      Location:130 → 242
      Nucleo_P87; Nucleopolyhedrovirus capsid protein P87
      cl25732
      Location:318 → 577
      SMC_N; RecF/RecN/SMC N terminal domain

    7. NM_028181.5 → NP_082457.3  cell cycle progression protein 1 isoform 2

      See identical proteins and their annotated locations for NP_082457.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 6. It encodes isoform 2, which has a distinct C-terminus and is shorter, compared to isoform 6.
      Source sequence(s)
      AK076325, AK134675, BC043049, CN721780
      Consensus CDS
      CCDS23334.1
      UniProtKB/Swiss-Prot
      Q640L3
      Related
      ENSMUSP00000045669.8, ENSMUST00000037977.15
      Conserved Domains (1) summary
      pfam10577
      Location:133 → 218
      UPF0560; uncharacterized protein family UPF0560

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      72892692..72923622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155316.1 → XP_036011209.1  cell cycle progression protein 1 isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:327 → 586
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07267
      Location:90 → 242
      Nucleo_P87; Nucleopolyhedrovirus capsid protein P87

    2. XM_036155318.1 → XP_036011211.1  cell cycle progression protein 1 isoform X5

      Conserved Domains (2) summary
      PLN02328
      Location:110 → 264
      PLN02328; lysine-specific histone demethylase 1 homolog
      COG1196
      Location:327 → 586
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_006511469.5 → XP_006511532.1  cell cycle progression protein 1 isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:318 → 577
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07267
      Location:90 → 242
      Nucleo_P87; Nucleopolyhedrovirus capsid protein P87

    4. XM_036155314.1 → XP_036011207.1  cell cycle progression protein 1 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:327 → 586
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07267
      Location:90 → 242
      Nucleo_P87; Nucleopolyhedrovirus capsid protein P87

    5. XM_036155317.1 → XP_036011210.1  cell cycle progression protein 1 isoform X3

      Conserved Domains (2) summary
      PLN02328
      Location:86 → 232
      PLN02328; lysine-specific histone demethylase 1 homolog
      COG1196
      Location:295 → 554
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_036155315.1 → XP_036011208.1  cell cycle progression protein 1 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:327 → 586
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07267
      Location:90 → 242
      Nucleo_P87; Nucleopolyhedrovirus capsid protein P87

    RNA

    1. XR_004935565.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q640L3.2 GenPept UniProtKB/Swiss-Prot:Q640L3

    Gene LinkOut

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