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    B3gnt3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 72297, updated on 27-Nov-2024

    Summary

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    Official Symbol
    B3gnt3provided by MGI
    Official Full Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3provided by MGI
    Primary source
    MGI:MGI:2152535
    See related
    Ensembl:ENSMUSG00000031803 AllianceGenome:MGI:2152535
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2210008L19Rik
    Summary
    Predicted to enable N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity. Predicted to be involved in poly-N-acetyllactosamine biosynthetic process and protein O-linked glycosylation. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Orthologous to human B3GNT3 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 175.6), duodenum adult (RPKM 146.7) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B3gnt3 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72144017..72155270, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71691373..71702626, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:74157112-74157221 Neighboring gene unc-13 homolog A Neighboring gene microRNA 6769b Neighboring gene STARR-positive B cell enhancer ABC_E5015 Neighboring gene STARR-positive B cell enhancer ABC_E10509 Neighboring gene STARR-seq mESC enhancer starr_21826 Neighboring gene Janus kinase 3 Neighboring gene insulin-like 3 Neighboring gene STARR-seq mESC enhancer starr_21829 Neighboring gene predicted gene 45756 Neighboring gene CCR4-NOT transcription complex, subunit 8 pseudogene Neighboring gene FCH domain only 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in poly-N-acetyllactosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly-N-acetyllactosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in poly-N-acetyllactosamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3
    Names
    BGnT-3
    beta-1,3-Gn-T3
    beta-1,3-N-acetylglucosaminyltransferase 3
    beta3Gn-T3
    core 1 beta-1,3-N-acetylglucosaminyltransferase
    core 1 extending beta-1,3-N-acetylglucosaminyltransferase
    core1-beta3GlcNAcT
    NP_082465.3
    XP_006509815.1
    XP_006509816.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028189.3 → NP_082465.3  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

      See identical proteins and their annotated locations for NP_082465.3

      Status: VALIDATED

      Source sequence(s)
      AC162033, AY039028, BY753510
      Consensus CDS
      CCDS22405.1
      UniProtKB/Swiss-Prot
      Q5JCS9, Q8R0U2, Q9D7Z2
      UniProtKB/TrEMBL
      Q3UNN7
      Related
      ENSMUSP00000034260.8, ENSMUST00000034260.9
      Conserved Domains (1) summary
      cl21608
      Location:122 → 311
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      72144017..72155270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509753.4 → XP_006509816.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_006509816.1

      UniProtKB/Swiss-Prot
      Q5JCS9, Q8R0U2, Q9D7Z2
      UniProtKB/TrEMBL
      Q3UNN7
      Conserved Domains (1) summary
      cl21608
      Location:122 → 311
      Galactosyl_T; Galactosyltransferase

    2. XM_006509752.4 → XP_006509815.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_006509815.1

      UniProtKB/Swiss-Prot
      Q5JCS9, Q8R0U2, Q9D7Z2
      UniProtKB/TrEMBL
      Q3UNN7
      Conserved Domains (1) summary
      cl21608
      Location:122 → 311
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JCS9.1 GenPept UniProtKB/Swiss-Prot:Q5JCS9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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