Tm7sf2 transmembrane 7 superfamily member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tm7sf2provided by MGI
Official Full Name: transmembrane 7 superfamily member 2provided by MGI
Primary source: MGI:MGI:1920416
See related: Ensembl:ENSMUSG00000024799 AllianceGenome:MGI:1920416
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ANG1; C14SR; Dhcr14; 3110041O18Rik
Summary: Enables delta14-sterol reductase activity. Involved in cholesterol biosynthetic process. Located in organelle membrane. Is expressed in several structures, including adrenal gland; alimentary system; eye; liver; and nervous system. Orthologous to human TM7SF2 (transmembrane 7 superfamily member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver adult (RPKM 170.8), liver E18 (RPKM 41.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.34 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6112851..6117880, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6062821..6067850, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tm7sf2 gene promotes adipocyte differentiation of mouse embryonic fibroblasts and improves insulin sensitivity.
Title: Tm7sf2 gene promotes adipocyte differentiation of mouse embryonic fibroblasts and improves insulin sensitivity.
Tm7sf2 deficiency during liver regeneration alters lipid metabolism and generates a stress condition, which, in turn, transiently unbalances hepatocytes cell cycle progression.
Title: Impaired cell proliferation in regenerating liver of 3 β-hydroxysterol Δ14-reductase (TM7SF2) knock-out mice.
The Tm7sf2 insufficiency is responsible for the inhibition of the NF-kappaB signaling.
Title: The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury.
the loss of Tm7sf2 alters the expression of proteins involved in epidermal differentiation by reducing the levels of cholesterol sulfate
Title: The loss of Tm7sf gene accelerates skin papilloma formation in mice.
These results show a significant increase in renal TNFalpha expression after tunicamycin exposure and in the oedematogenic response in Tm7sf2(-/-) mice.
Title: A novel role for Tm7sf2 gene in regulating TNFα expression.
several genes involved in cell-cycle progression are downregulated in the liver of Tm7sf2((-/-)) mice, whereas genes involved in xenobiotic metabolism are upregulated.
Title: Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tm7sf2 (e-PCR), detects polymorphism
- UniSTS:547159

AI837850 (e-PCR)
- UniSTS:181164

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NADP binding	ISS Inferred from Sequence or Structural Similarity more info
enables delta14-sterol reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables delta14-sterol reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables delta14-sterol reductase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in organelle membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: delta(14)-sterol reductase TM7SF2

Names: 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; delta-14-SR; sterol C14-reductase

NP_082730.2

EC 1.3.1.70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.