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    ano1.S anoctamin 1, calcium activated chloride channel S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 735089, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ano1.S
    Official Full Name
    anoctamin 1, calcium activated chloride channel S homeolog
    Primary source
    Xenbase:XB-GENE-17340858
    Locus tag
    XELAEV_18024491mg
    See related
    EnsemblRapid:ENSXLAG00005020585 AllianceGenome:Xenbase:XB-GENE-17340858
    Gene type
    protein coding
    RefSeq status
    PREDICTED
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    ano2; dog1; taos2; xano2; oraov2; tmem16a; xTMEM16A
    Summary
    Predicted to enable protein dimerization activity. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ano1.S in Genome Data Viewer
    Location:
    chromosome: 4S
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (15117850..15237876)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (14545548..14643423)

    Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) S homeolog Neighboring gene fibroblast growth factor 3 S homeolog Neighboring gene ARF GTPase activating protein 2 S homeolog Neighboring gene UPF0705 protein C11orf49 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylinositol 4,5-bisphosphate (PIP(2)) and Ca(2+) are both required to open the Cl(-) channel TMEM16A. Tembo M, et al. J Biol Chem, 2019 Aug 16. PMID 31266809, Free PMC Article
    2. Cloning and heterologous expression of new xANO2 from Xenopus laevis. Ryu RH, et al. Biochem Biophys Res Commun, 2011 May 20. PMID 21521635
    3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results reveal that TMEM16A regulation is more complicated than it initially appeared; not only is Ca(2+) necessary to signal TMEM16a opening, but PIP2 is also required.
      Title: Phosphatidylinositol 4,5-bisphosphate (PIP(2)) and Ca(2+) are both required to open the Cl(-) channel TMEM16A.
    2. xANO2 was regarded as a new TMEM16A belonging to the Xenopus anoctamin family.
      Title: Cloning and heterologous expression of new xANO2 from Xenopus laevis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC115353

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC735089

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001096548.1 → NP_001090017.1  uncharacterized protein LOC735089

      See identical proteins and their annotated locations for NP_001090017.1

      Status: PREDICTED

      Source sequence(s)
      BC094127
      UniProtKB/TrEMBL
      Q52KZ9
      Conserved Domains (1) summary
      pfam04547
      Location:78 → 280
      Anoctamin; Calcium-activated chloride channel

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      15117850..15237876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018259775.2 → XP_018115264.1  uncharacterized protein LOC735089 isoform X3

      UniProtKB/TrEMBL
      A0A8J0V4W0, F2Z9C2
      Conserved Domains (2) summary
      pfam04547
      Location:318 → 924
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:53 → 315
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    2. XM_041591461.1 → XP_041447395.1  uncharacterized protein LOC735089 isoform X3

      UniProtKB/TrEMBL
      A0A8J0V4W0, F2Z9C2
      Conserved Domains (2) summary
      pfam04547
      Location:318 → 924
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:53 → 315
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    3. XM_041591459.1 → XP_041447393.1  uncharacterized protein LOC735089 isoform X1

      UniProtKB/TrEMBL
      A0A8J1N1U5, F2Z9C2

    4. XM_041591460.1 → XP_041447394.1  uncharacterized protein LOC735089 isoform X2

      UniProtKB/TrEMBL
      A0A8J1MZT1, A0A974CY37
      Related
      ENSXLAP00005060500.1, ENSXLAT00005061949.1

    5. XM_041591462.1 → XP_041447396.1  uncharacterized protein LOC735089 isoform X4

      UniProtKB/TrEMBL
      A0A8J1N110, F2Z9C2

    6. XM_041591464.1 → XP_041447398.1  uncharacterized protein LOC735089 isoform X5

      UniProtKB/TrEMBL
      A0A8J1N1V1, A0A974CY37
      Related
      ENSXLAP00005060531.1, ENSXLAT00005061980.1

    7. XM_041591465.1 → XP_041447399.1  uncharacterized protein LOC735089 isoform X6

      UniProtKB/TrEMBL
      A0A8J1MZT7, F2Z9C2
      Related
      ENSXLAP00005060431.1, ENSXLAT00005061881.1
    Nucleotide Protein Strain
    Heading Accession and Version

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