Uba7 ubiquitin-like modifier activating enzyme 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uba7provided by MGI
Official Full Name: ubiquitin-like modifier activating enzyme 7provided by MGI
Primary source: MGI:MGI:1349462
See related: Ensembl:ENSMUSG00000032596 AllianceGenome:MGI:1349462
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ube1l; 1300004C08Rik
Summary: Enables ISG15 activating enzyme activity. Acts upstream of or within ISG15-protein conjugation and modification-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in liver lobe and thymus primordium. Orthologous to human UBA7 (ubiquitin like modifier activating enzyme 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 54.8), thymus adult (RPKM 45.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 59.07 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (107852766..107861255)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (107975567..107984056)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibitor-sensitive tyrosine kinase controls the population heterogeneity of basal STAT1 activity in Ube1l deficient fibroblasts.
Title: AG490 and PF431396 Sensitive Tyrosine Kinase Control the Population Heterogeneity of Basal STAT1 Activity in Ube1l Deficient Cells.
Bone marrow transplantation experiment revealed a 50% reduction in repopulation potential of Ube1L-deficient cells at 3weeks posttransplantation, but no differences at 6 and 12weeks.
Title: Hematopoietic cells from Ube1L-deficient mice exhibit an impaired proliferation defect under the stress of bone marrow transplantation.
Ube1l is not a tumor suppressor gene in K-ras(LA2) lung cancer mouse model.
Title: Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-rasLA2 mice.
The importance of UbE1L was confirmed by demonstrating that mice lacking this ISG15 E1 enzyme were highly susceptible to Sindbis virus infection.
Title: ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus.
Both UbE1L(-/-) and ISG15(-/-) mice display increased susceptibility to influenza B virus infection, including non-mouse-adapted strains.
Title: Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection.
UBE1L and protein ISGylation are not critical for IFN-alpha/beta signaling via JAK/STAT activation.
Title: Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ISG15 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ISG15 activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables ISG15 activating enzyme activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin activating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in ISG15-protein conjugation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ISG15-protein conjugation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ISG15-protein conjugation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ISG15-protein conjugation	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within modification-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin-like modifier-activating enzyme 7

Names: ubiquitin-activating enzyme 7; ubiquitin-activating enzyme E1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023738.4 → NP_076227.1 ubiquitin-like modifier-activating enzyme 7

See identical proteins and their annotated locations for NP_076227.1

Status: PROVISIONAL

Source sequence(s)

AL731808

Consensus CDS

CCDS40764.1

UniProtKB/Swiss-Prot

Q9DBK7

UniProtKB/TrEMBL

Q8BTN4

Related

ENSMUSP00000035216.5, ENSMUST00000035216.11

Conserved Domains (4) summary

cd01491
Location:5 → 386

Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...

TIGR01408
Location:1 → 961

Ube1; ubiquitin-activating enzyme E1

pfam16191
Location:254 → 317

E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle

cl22428
Location:421 → 932

E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...