VIPR2 vasoactive intestinal peptide receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: VIPR2provided by HGNC
Official Full Name: vasoactive intestinal peptide receptor 2provided by HGNC
Primary source: HGNC:HGNC:12695
See related: Ensembl:ENSG00000106018 MIM:601970; AllianceGenome:HGNC:12695
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: VPAC2; VPAC2R; VIP-R-2; VPCAP2R; PACAP-R3; DUP7q36.3; PACAP-R-3; C16DUPq36.3
Summary: This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
Expression: Broad expression in ovary (RPKM 1.9), brain (RPKM 1.9) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q36.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (159028175..159144867, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (160254532..160371379, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (158820866..158937559, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer.
Title: VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer.
Outdoor time influences VIPR2 polymorphism rs2071623 to regulate axial length in Han Chinese children.
Title: Outdoor time influences VIPR2 polymorphism rs2071623 to regulate axial length in Han Chinese children.
Seaweed intake modulates the association between VIPR2 variants and the incidence of metabolic syndrome in middle-aged Koreans.
Title: Seaweed intake modulates the association between VIPR2 variants and the incidence of metabolic syndrome in middle-aged Koreans.
TMEM132D and VIPR2 Polymorphisms as Genetic Risk Loci for Retinal Detachment: A Genome-Wide Association Study and Polygenic Risk Score Analysis.
Title: TMEM132D and VIPR2 Polymorphisms as Genetic Risk Loci for Retinal Detachment: A Genome-Wide Association Study and Polygenic Risk Score Analysis.
Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway.
Title: Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway.
PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
Title: PAC(1), VPAC(1), and VPAC(2) Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys(25)-Cys(192)) formation of functional significance for VIPR2.
Title: AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys(25)-Cys(192)) formation of functional significance for VIPR2.
Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia.
Title: Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia.
Dysfunction of VIPR2 leads to myopia in humans and mice.
Title: Dysfunction of VIPR2 leads to myopia in humans and mice.
Association of VIPR2 and ZMAT4 with high myopia.
Title: Association of VIPR2 and ZMAT4 with high myopia.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-171691 (e-PCR)
- UniSTS:184581

RH93213 (e-PCR)
- UniSTS:92178

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

D7S749 (e-PCR)
- UniSTS:39222

D7S427 (e-PCR)
- UniSTS:36432

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables pituitary adenylate cyclase-activating polypeptide receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables vasoactive intestinal polypeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vasoactive intestinal polypeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: vasoactive intestinal polypeptide receptor 2

Names: PACAP type III receptor; VIP and PACAP receptor 2; helodermin-preferring VIP receptor; pituitary adenylate cyclase-activating polypeptide type III receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001304522.2 → NP_001291451.1 vasoactive intestinal polypeptide receptor 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_001291451.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.

Source sequence(s)

AC004863, AK131406, AK308955, KJ534961

UniProtKB/TrEMBL

X5DP12

Conserved Domains (2) summary

smart00008
Location:52 → 118

HormR; Domain present in hormone receptors

cl21561
Location:120 → 291

7tm_4; Olfactory receptor
NM_001308259.1 → NP_001295188.1 vasoactive intestinal polypeptide receptor 2 isoform 3

See identical proteins and their annotated locations for NP_001295188.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC004863, AK131406, CA449700

Consensus CDS

CCDS78295.1

UniProtKB/Swiss-Prot

P41587

Related

ENSP00000366860.3, ENST00000377633.7

Conserved Domains (1) summary

pfam00002
Location:107 → 355

7tm_2; 7 transmembrane receptor (Secretin family)
NM_003382.5 → NP_003373.2 vasoactive intestinal polypeptide receptor 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_003373.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC004863, AC007269, AF027390, KC877184

Consensus CDS

CCDS5950.1

UniProtKB/Swiss-Prot

P41587, Q13053, Q15870, Q53Y09, Q6ZN22, Q9UCW0

UniProtKB/TrEMBL

X5D7Q6

Related

ENSP00000262178.2, ENST00000262178.7

Conserved Domains (2) summary

smart00008
Location:52 → 118

HormR; Domain present in hormone receptors

cd15986
Location:123 → 392

7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

RNA

NR_130758.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC004863, AC007269, AF027390, KC877184