U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TOP2 topoisomerase [ Thalassiosira pseudonana CCMP1335 ]

    Gene ID: 7446883, updated on 21-Dec-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    TOP2
    Gene description
    topoisomerase
    Locus tag
    THAPSDRAFT_36522
    Gene type
    protein coding
    RNA name
    topoisomerase
    RefSeq status
    PROVISIONAL
    Organism
    Thalassiosira pseudonana CCMP1335 (strain: CCMP1335)
    Lineage
    Eukaryota; Stramenopiles; Bacillariophyta; Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales; Thalassiosiraceae; Thalassiosira
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TOP2 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    5
    Sequence:
    Chromosome: 10; NC_012073.1 (749384..753213)

    Chromosome 10 - NC_012073.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene indole-3-glycerol-phosphate synthase Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_012073.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism. Armbrust EV, et al. Science, 2004 Oct 1. PMID 15459382
    2. The Phaeodactylum genome reveals the evolutionary history of diatom genomes. Bowler C, et al. Nature, 2008 Nov 13. PMID 18923393
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sister chromatid segregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Names
    topoisomerase
    XP_002292696.1
    • Supported by sequence simularity only-no EST data

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_012073.1 Reference assembly

      Range
      749384..753213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002292660.1 → XP_002292696.1  topoisomerase, partial [Thalassiosira pseudonana CCMP1335]

      See identical proteins and their annotated locations for XP_002292696.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      B8C9P0
      Conserved Domains (6) summary
      cd03365
      Location:437 → 557
      TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
      PLN03128
      Location:1 → 1153
      PLN03128; DNA topoisomerase 2; Provisional
      cd00187
      Location:689 → 1148
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      cd03481
      Location:255 → 400
      TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
      pfam02518
      Location:60 → 154
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
      pfam16898
      Location:555 → 689
      TOPRIM_C; C-terminal associated domain of TOPRIM
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials