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    Mmd2 monocyte to macrophage differentiation-associated 2 [ Mus musculus (house mouse) ]

    Gene ID: 75104, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mmd2provided by MGI
    Official Full Name
    monocyte to macrophage differentiation-associated 2provided by MGI
    Primary source
    MGI:MGI:1922354
    See related
    Ensembl:ENSMUSG00000039533 AllianceGenome:MGI:1922354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930518M15Rik
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in several processes, including positive regulation of Ras protein signal transduction; positive regulation of neuron differentiation; and positive regulation of protein kinase activity. Predicted to be located in Golgi membrane and perinuclear region of cytoplasm. Is expressed in several structures, including gonad; intestine; liver; nervous system; and pancreas. Orthologous to human MMD2 (monocyte to macrophage differentiation associated 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 31.8), cortex adult (RPKM 26.0) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mmd2 in Genome Data Viewer
    Location:
    5 G2; 5 81.53 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142549229..142594886, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142563480..142608936, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Ras association and DIL domains Neighboring gene predicted gene, 38732 Neighboring gene poly (A) polymerase beta (testis specific) Neighboring gene STARR-positive B cell enhancer ABC_E8090 Neighboring gene STARR-positive B cell enhancer ABC_E10363 Neighboring gene predicted gene, 31274 Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene STARR-seq mESC enhancer starr_14752

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10. Góñez LJ, et al. Mol Med, 2008 Nov-Dec. PMID 18769639, Free PMC Article
    2. Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice. Zhao L, et al. Sex Dev, 2022. PMID 35306493
    3. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Kang P, et al. Neuron, 2012 Apr 12. PMID 22500632, Free PMC Article
    4. Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons. Machado CB, et al. Development, 2014 Feb. PMID 24496616, Free PMC Article
    5. Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Yu K, et al. Development, 2013 Apr. PMID 23482494, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables pore-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    monocyte to macrophage differentiation factor 2
    Names
    progestin and adipoQ receptor family member 10
    progestin and adipoQ receptor family member X

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417873.1 → NP_001404802.1  monocyte to macrophage differentiation factor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158310

    2. NM_001417874.1 → NP_001404803.1  monocyte to macrophage differentiation factor 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158310

    3. NM_175217.7 → NP_780426.1  monocyte to macrophage differentiation factor 2 isoform 1

      See identical proteins and their annotated locations for NP_780426.1

      Status: VALIDATED

      Source sequence(s)
      AC158310
      Consensus CDS
      CCDS39363.1
      UniProtKB/Swiss-Prot
      Q8R189
      UniProtKB/TrEMBL
      Q3V1Z9
      Related
      ENSMUSP00000039357.8, ENSMUST00000037048.9
      Conserved Domains (1) summary
      cl03831
      Location:35 → 235
      HlyIII; Haemolysin-III related

    RNA

    1. NR_184650.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158310

    2. NR_184651.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158310

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      142549229..142594886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165572.1 → XP_036021465.1  monocyte to macrophage differentiation factor 2 isoform X2

    2. XM_011240988.4 → XP_011239290.1  monocyte to macrophage differentiation factor 2 isoform X1

      Conserved Domains (1) summary
      cl03831
      Location:17 → 217
      HlyIII; Haemolysin-III related
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R189.1 GenPept UniProtKB/Swiss-Prot:Q8R189

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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