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    Lsm8 LSM8 homolog, U6 small nuclear RNA associated [ Mus musculus (house mouse) ]

    Gene ID: 76522, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lsm8provided by MGI
    Official Full Name
    LSM8 homolog, U6 small nuclear RNA associatedprovided by MGI
    Primary source
    MGI:MGI:1923772
    See related
    Ensembl:ENSMUSG00000044155 AllianceGenome:MGI:1923772
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lsm8; Naa38; 2010003I05Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of Lsm2-8 complex; U2-type precatalytic spliceosome; and spliceosomal snRNP complex. Is expressed in caudal ganglionic eminence and medial ganglionic eminence. Orthologous to human LSM8 (LSM8 homolog, U6 small nuclear RNA associated). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 49.8), liver E14 (RPKM 30.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lsm8 in Genome Data Viewer
    Location:
    6 A2; 6 8.16 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (18848634..18854051)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (18848635..18854052)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23648 Neighboring gene STARR-seq mESC enhancer starr_15271 Neighboring gene STARR-seq mESC enhancer starr_15272 Neighboring gene STARR-positive B cell enhancer mm9_chr6:18798382-18798683 Neighboring gene predicted gene 5874 Neighboring gene STARR-seq mESC enhancer starr_15273 Neighboring gene ankyrin repeat domain 7 Neighboring gene STARR-seq mESC enhancer starr_15274 Neighboring gene STARR-seq mESC enhancer starr_15275 Neighboring gene protein disulfide isomerase associated 6 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain. Cajigas I, et al. Development, 2021 Mar 15. PMID 33593819, Free PMC Article
    2. LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice. Wang X, et al. Mol Cell, 2020 Mar 5. PMID 32017896
    3. USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis. Kim J, et al. Mol Cell Biol, 2020 Oct 13. PMID 32839293, Free PMC Article
    4. The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain. Cajigas I, et al. Mol Cell, 2018 Sep 20. PMID 30146317, Free PMC Article
    5. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Lsm2-8 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Lsm2-8 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U6 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U6 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LSM8 homolog, U6 small nuclear RNA associated
    Names
    U6 snRNA-associated Sm-like protein LSm8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133939.1 → NP_598700.1  LSM8 homolog, U6 small nuclear RNA associated

      Status: PROVISIONAL

      Source sequence(s)
      BC019458
      Consensus CDS
      CCDS39433.1
      UniProtKB/Swiss-Prot
      Q3TIX3, Q6ZWM4
      Related
      ENSMUSP00000057238.9, ENSMUST00000056398.11
      Conserved Domains (1) summary
      cd01727
      Location:3 → 92
      LSm8; Like-Sm protein 8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      18848634..18854051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZWM4.3 GenPept UniProtKB/Swiss-Prot:Q6ZWM4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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