Mettl15 methyltransferase like 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mettl15provided by MGI
Official Full Name: methyltransferase like 15provided by MGI
Primary source: MGI:MGI:1924144
See related: Ensembl:ENSMUSG00000057234 AllianceGenome:MGI:1924144
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mett5d1; 0610027B03Rik
Summary: Predicted to enable rRNA (cytosine-N4-)-methyltransferase activity. Predicted to be involved in rRNA base methylation. Predicted to be active in mitochondrial matrix. Is expressed in neocortex. Orthologous to several human genes including METTL15 (methyltransferase 15, mitochondrial 12S rRNA N4-cytidine). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 2.5), liver E14 (RPKM 2.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E3; 2 56.52 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (108922642..109111100, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (109092297..109281330, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.
Title: Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.
METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue.
Title: METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

MT514 (e-PCR)
- UniSTS:129025

D2Mit162.1 (e-PCR), detects polymorphism
- UniSTS:129026

MHAa53a12.seq (e-PCR)
- UniSTS:125193

AI303697 (e-PCR)
- UniSTS:158996

AW049952 (e-PCR)
- UniSTS:179250

18.MMHAP34FRF9.seq (e-PCR)
- UniSTS:123380

NoName (e-PCR)
- UniSTS:488951

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables rRNA (cytosine-N4-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (cytosine-N4-)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables rRNA (cytosine-N4-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in rRNA base methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA base methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 12S rRNA N4-methylcytidine methyltransferase

Names: 12S rRNA m4C methyltransferase; methyltransferase 5 domain containing 1; methyltransferase 5 domain-containing protein 1; methyltransferase-like protein 15; probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1; probable methyltransferase-like protein 15; putative S-adenosyl-L-methionine-dependent methyltransferase METT5D1

NP_001405755.1

EC 2.1.1.-

NP_001405756.1

EC 2.1.1.-

NP_001405757.1

EC 2.1.1.-

NP_001405758.1

EC 2.1.1.-

NP_001405759.1

EC 2.1.1.-

NP_001405760.1

EC 2.1.1.-

NP_001405761.1

EC 2.1.1.-

NP_001405762.1

EC 2.1.1.-

NP_084066.2

EC 2.1.1.-

XP_036018578.1

EC 2.1.1.-

XP_036018579.1

EC 2.1.1.-

XP_036018580.1

EC 2.1.1.-

XP_036018581.1

EC 2.1.1.-

XP_036018582.1

EC 2.1.1.-

XP_036018583.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418826.1 → NP_001405755.1 12S rRNA N4-methylcytidine methyltransferase isoform a

Status: VALIDATED

Source sequence(s)

AL691430, BX813309, BX813328

UniProtKB/Swiss-Prot

Q3KQI4, Q9DCL4
NM_001418827.1 → NP_001405756.1 12S rRNA N4-methylcytidine methyltransferase isoform a

Status: VALIDATED

Source sequence(s)

AL691430, BX813309, BX813328

UniProtKB/Swiss-Prot

Q3KQI4, Q9DCL4
NM_001418828.1 → NP_001405757.1 12S rRNA N4-methylcytidine methyltransferase isoform a

Status: VALIDATED

Source sequence(s)

AL691430, BX813309, BX813328

UniProtKB/Swiss-Prot

Q3KQI4, Q9DCL4
NM_001418829.1 → NP_001405758.1 12S rRNA N4-methylcytidine methyltransferase isoform b

Status: VALIDATED

Source sequence(s)

AL691430, BX813309, BX813328

Related

ENSMUSP00000116829.2, ENSMUST00000147770.2
NM_001418830.1 → NP_001405759.1 12S rRNA N4-methylcytidine methyltransferase isoform b

Status: VALIDATED

Source sequence(s)

AL691430, BX813309, BX813328
NM_001418831.1 → NP_001405760.1 12S rRNA N4-methylcytidine methyltransferase isoform b

Status: VALIDATED

Source sequence(s)

AL691430, BX813309, BX813328
NM_001418832.1 → NP_001405761.1 12S rRNA N4-methylcytidine methyltransferase isoform b

Status: VALIDATED

Source sequence(s)

AL691430, BX813309, BX813328
NM_001418833.1 → NP_001405762.1 12S rRNA N4-methylcytidine methyltransferase isoform c

Status: VALIDATED

Source sequence(s)

AL691430, BX813309
NM_029790.4 → NP_084066.2 12S rRNA N4-methylcytidine methyltransferase isoform a

See identical proteins and their annotated locations for NP_084066.2

Status: VALIDATED

Source sequence(s)

AL691430, BX813309, BX813328

Consensus CDS

CCDS16506.1

UniProtKB/Swiss-Prot

Q3KQI4, Q9DCL4

Related

ENSMUSP00000080337.4, ENSMUST00000081631.10

Conserved Domains (1) summary

PRK00050
Location:72 → 406

PRK00050; 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH

RNA

NR_184831.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL691430, BX813309, BX813328
NR_184832.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL691430, BX813309, BX813328
NR_184833.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL691430, BX813309, BX813328
NR_184834.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL691430, BX813309, BX813328

Related

ENSMUST00000147376.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

108922642..109111100 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162689.1 → XP_036018582.1 12S rRNA N4-methylcytidine methyltransferase isoform X3

Conserved Domains (1) summary

cl17173
Location:8 → 253

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036162688.1 → XP_036018581.1 12S rRNA N4-methylcytidine methyltransferase isoform X2

Conserved Domains (1) summary

cl17173
Location:2 → 312

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036162690.1 → XP_036018583.1 12S rRNA N4-methylcytidine methyltransferase isoform X3

Conserved Domains (1) summary

cl17173
Location:8 → 253

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036162685.1 → XP_036018578.1 12S rRNA N4-methylcytidine methyltransferase isoform X2

Conserved Domains (1) summary

cl17173
Location:2 → 312

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036162686.1 → XP_036018579.1 12S rRNA N4-methylcytidine methyltransferase isoform X2

Conserved Domains (1) summary

cl17173
Location:2 → 312

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036162687.1 → XP_036018580.1 12S rRNA N4-methylcytidine methyltransferase isoform X2

Conserved Domains (1) summary

cl17173
Location:2 → 312

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...