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    Sapcd1 suppressor APC domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 78376, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sapcd1provided by MGI
    Official Full Name
    suppressor APC domain containing 1provided by MGI
    Primary source
    MGI:MGI:2388100
    See related
    Ensembl:ENSMUSG00000036185 AllianceGenome:MGI:2388100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G7d; Ng23; 2810436B06Rik
    Summary
    Is expressed in brain; cerebellum; lens vesicle; and submandibular gland. Orthologous to human SAPCD1 (suppressor APC domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 7.3), limb E14.5 (RPKM 4.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sapcd1 in Genome Data Viewer
    Location:
    17 B1; 17 18.56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35244935..35247600, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35025959..35028557, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 17, human D6S56E 5 Neighboring gene STARR-positive B cell enhancer ABC_E1941 Neighboring gene STARR-positive B cell enhancer ABC_E7526 Neighboring gene valyl-tRNA synthetase 1 Neighboring gene von Willebrand factor A domain containing 7 Neighboring gene predicted gene, 52318 Neighboring gene mutS homolog 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:35183800-35183983 Neighboring gene STARR-positive B cell enhancer ABC_E8671 Neighboring gene STARR-seq mESC enhancer starr_42445 Neighboring gene predicted gene, 23421 Neighboring gene chloride intracellular channel 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genotype versus phenotype: conflicting results in mapping a lung tumor susceptibility locus to the G7c recombination interval in the mouse MHC class III region. van Kooij M, et al. Immunogenetics, 2001 Oct. PMID 11797099
    2. iSyTE: integrated Systems Tool for Eye gene discovery. Lachke SA, et al. Invest Ophthalmol Vis Sci, 2012 Mar. PMID 22323457, Free PMC Article
    3. The mouse as a model for the effects of MHC genes on human disease. Allcock RJ, et al. Immunol Today, 2000 Jul. PMID 10871872
    4. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. Xie T, et al. Genome Res, 2003 Dec. PMID 14656967, Free PMC Article
    5. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    suppressor APC domain-containing protein 1
    Names
    protein G7d

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023893.4 → NP_076382.3  suppressor APC domain-containing protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
      Source sequence(s)
      AK019275, BC147772, BF465693
      Consensus CDS
      CCDS37594.1
      UniProtKB/Swiss-Prot
      B2RWH1, Q9CY86, Q9Z1Q7
      Related
      ENSMUSP00000047448.3, ENSMUST00000040151.9
      Conserved Domains (1) summary
      pfam11414
      Location:35 → 114
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

    RNA

    1. NR_028258.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of an exon and is missing a portion of the 3' UTR compared to variant 1. The alternate splice junction causes a frameshift and makes this transcript a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to be protein-coding.
      Source sequence(s)
      BC147772, BF465693, CF739520
      Related
      ENSMUST00000174037.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35244935..35247600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250145.2 → XP_030106005.1  suppressor APC domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B2RWH1, Q9CY86, Q9Z1Q7
      Conserved Domains (1) summary
      pfam11414
      Location:35 → 114
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

    2. XM_036160845.1 → XP_036016738.1  suppressor APC domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam11414
      Location:57 → 132
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

    3. XM_036160843.1 → XP_036016736.1  suppressor APC domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam11414
      Location:57 → 132
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY86.2 GenPept UniProtKB/Swiss-Prot:Q9CY86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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