Wwox WW domain-containing oxidoreductase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wwoxprovided by MGI
Official Full Name: WW domain-containing oxidoreductaseprovided by MGI
Primary source: MGI:MGI:1931237
See related: Ensembl:ENSMUSG00000004637 AllianceGenome:MGI:1931237
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: WOX1; 5330426P09Rik; 9030416C10Rik
Summary: Enables enzyme binding activity. Contributes to transcription coactivator activity. Involved in cellular response to transforming growth factor beta stimulus; positive regulation of extrinsic apoptotic signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including apoptotic signaling pathway; osteoblast differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in mitochondrion and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; hemolymphoid system gland; and skeleton. Used to study autosomal recessive spinocerebellar ataxia 12. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 2.7), adrenal adult (RPKM 2.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 60.99 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (115166377..116079451)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (114439635..115352712)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endothelial knockdown of the tumor suppressor, WWOX, increases inflammation in ventilator-induced lung injury.
Title: Endothelial knockdown of the tumor suppressor, WWOX, increases inflammation in ventilator-induced lung injury.
WWOX promotes osteosarcoma development via upregulation of Myc.
Title: WWOX promotes osteosarcoma development via upregulation of Myc.
Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis.
Title: Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis.
Loss of fragile WWOX gene leads to senescence escape and genome instability.
Title: Loss of fragile WWOX gene leads to senescence escape and genome instability.
WWOX activates autophagy to alleviate lipopolysaccharide-induced acute lung injury by regulating mTOR.
Title: WWOX activates autophagy to alleviate lipopolysaccharide-induced acute lung injury by regulating mTOR.
Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice.
Title: Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice.
Neuronal deletion of Wwox, associated with WOREE syndrome, causes epilepsy and myelin defects.
Title: Neuronal deletion of Wwox, associated with WOREE syndrome, causes epilepsy and myelin defects.
Cigarette Smoke and Nicotine-Containing Electronic-Cigarette Vapor Downregulate Lung WWOX Expression, Which Is Associated with Increased Severity of Murine Acute Respiratory Distress Syndrome.
Title: Cigarette Smoke and Nicotine-Containing Electronic-Cigarette Vapor Downregulate Lung WWOX Expression, Which Is Associated with Increased Severity of Murine Acute Respiratory Distress Syndrome.
Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3beta-mediated epileptic seizure activity in mice.
Title: Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice.
The studies uncover an unforeseen role of the tumor suppressor WWOX in whole-body glucose homeostasis and highlight the intimate relationship between cancer progression and metabolic disorders, particularly obesity and type-2 diabetes.
Title: WWOX somatic ablation in skeletal muscles alters glucose metabolism.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Gene trapped (2) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126125 (e-PCR)
- UniSTS:162837

D8Mit88 (e-PCR), detects polymorphism
- UniSTS:131634

37.MMHAP47FLE4.seq (e-PCR)
- UniSTS:124234

D8Mit200 (e-PCR), detects polymorphism
- UniSTS:131408

D8Mit214 (e-PCR), detects polymorphism
- UniSTS:131423

D8Mit244 (e-PCR), detects polymorphism
- UniSTS:131455

38.MMHAP84FLE5.seq (e-PCR)
- UniSTS:124299

D8Mit273 (e-PCR), detects polymorphism
- UniSTS:131484

D8Mit319 (e-PCR), detects polymorphism
- UniSTS:131534

D8Mit320 (e-PCR), detects polymorphism
- UniSTS:131536

RH126335 (e-PCR)
- UniSTS:163043

AU028399 (e-PCR)
- UniSTS:112365

AU049464 (e-PCR)
- UniSTS:145911

D8Mit116 (e-PCR), detects polymorphism
- UniSTS:131322

D8Mit117 (e-PCR), detects polymorphism
- UniSTS:131323

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
colocalizes_with microvillus	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: WW domain-containing oxidoreductase

Names: WW-domain oxidoreductase

NP_001402027.1

EC 1.1.1.-

NP_001402028.1

EC 1.1.1.-

NP_001402029.1

EC 1.1.1.-

NP_001402030.1

EC 1.1.1.-

NP_062519.2

EC 1.1.1.-

XP_006531573.1

EC 1.1.1.-

XP_006531574.1

EC 1.1.1.-

XP_006531575.1

EC 1.1.1.-

XP_006531576.1

EC 1.1.1.-

XP_006531578.1

EC 1.1.1.-

XP_011246858.1

EC 1.1.1.-

XP_011246859.1

EC 1.1.1.-

XP_011246860.1

EC 1.1.1.-

XP_036010283.1

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415098.1 → NP_001402027.1 WW domain-containing oxidoreductase isoform 2

Status: VALIDATED

Source sequence(s)

AC110576, AC129777, AC151980
NM_001415099.1 → NP_001402028.1 WW domain-containing oxidoreductase isoform 3

Status: VALIDATED

Source sequence(s)

AC110576, AC129777, AC151980
NM_001415100.1 → NP_001402029.1 WW domain-containing oxidoreductase isoform 4

Status: VALIDATED

Source sequence(s)

AC110576, AC151980

Related

ENSMUSP00000125626.2, ENSMUST00000160862.8
NM_001415101.1 → NP_001402030.1 WW domain-containing oxidoreductase isoform 5

Status: VALIDATED

Source sequence(s)

AC110576, AC142145, AC151980
NM_019573.4 → NP_062519.2 WW domain-containing oxidoreductase isoform 1

See identical proteins and their annotated locations for NP_062519.2

Status: VALIDATED

Source sequence(s)

AC110576, AC129777, AC151980

Consensus CDS

CCDS22691.1

UniProtKB/Swiss-Prot

Q8C8J6, Q91WL8, Q920Y2, Q9D2B3, Q9D339, Q9JLF5

Related

ENSMUSP00000004756.8, ENSMUST00000004756.14

Conserved Domains (3) summary

cd09809
Location:124 → 407

human_WWOX_like_SDR_c-like; human WWOX (WW domain-containing oxidoreductase)-like, classical (c)-like SDRs

PRK06196
Location:107 → 404

PRK06196; oxidoreductase; Provisional

cd00201
Location:19 → 47

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

115166377..116079451

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531515.5 → XP_006531578.1 WW domain-containing oxidoreductase isoform X11

Conserved Domains (3) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 209

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006531510.5 → XP_006531573.1 WW domain-containing oxidoreductase isoform X1

Conserved Domains (3) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 352

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006531512.4 → XP_006531575.1 WW domain-containing oxidoreductase isoform X4

Conserved Domains (3) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 352

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_011248556.3 → XP_011246858.1 WW domain-containing oxidoreductase isoform X2

Conserved Domains (3) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 352

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_011248557.4 → XP_011246859.1 WW domain-containing oxidoreductase isoform X6

Conserved Domains (3) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 352

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006531511.5 → XP_006531574.1 WW domain-containing oxidoreductase isoform X3

Conserved Domains (3) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 352

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_011248558.4 → XP_011246860.1 WW domain-containing oxidoreductase isoform X7

UniProtKB/Swiss-Prot

Q91WL8

Related

ENSMUSP00000104736.3, ENSMUST00000109108.9

Conserved Domains (3) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 353

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006531513.4 → XP_006531576.1 WW domain-containing oxidoreductase isoform X8

Conserved Domains (3) summary

cd00201
Location:60 → 90

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:18 → 47

WW; WW domain

cl21454
Location:124 → 352

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_036154390.1 → XP_036010283.1 WW domain-containing oxidoreductase isoform X10

Conserved Domains (1) summary

cl21454
Location:17 → 251

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins