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    PF3D7_1254800 rifin [ Plasmodium falciparum 3D7 ]

    Gene ID: 811579, updated on 14-Nov-2024

    Summary

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    Gene symbol
    PF3D7_1254800
    Gene description
    rifin
    Locus tag
    PF3D7_1254800
    See related
    PlasmoDB:PF3D7_1254800; VEuPathDB:PF3D7_1254800
    Gene type
    protein coding
    RNA name
    rifin
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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    Genomic context

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    See PF3D7_1254800 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    2
    Sequence:
    Chromosome: 12; NC_037284.1 (2228632..2229740, complement)

    Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene stevor Neighboring gene rifin Neighboring gene Plasmodium exported protein, unknown function, fragment Neighboring gene rifin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037284.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic diversity and natural selection of rif gene (PF3D7_1254800) in the Plasmodium falciparum global populations. Xu SJ, et al. Mol Biochem Parasitol, 2023 Jun. PMID 36918126
    2. Structural basis for RIFIN-mediated activation of LILRB1 in malaria. Harrison TE, et al. Nature, 2020 Nov. PMID 32650338, Free PMC Article
    3. Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptor LILRB2. Sakoguchi A, et al. Biochem Biophys Res Commun, 2021 Apr 9. PMID 33647792
    4. Characterization of SPP inhibitors suppressing propagation of HCV and protozoa. Hirano J, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29187532, Free PMC Article
    5. RIFINs are adhesins implicated in severe Plasmodium falciparum malaria. Goel S, et al. Nat Med, 2015 Apr. PMID 25751816

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic diversity and natural selection of rif gene (PF3D7_1254800) in the Plasmodium falciparum global populations.
      Title: Genetic diversity and natural selection of rif gene (PF3D7_1254800) in the Plasmodium falciparum global populations.
    2. Structural basis for RIFIN-mediated activation of LILRB1 in malaria.
      Title: Structural basis for RIFIN-mediated activation of LILRB1 in malaria.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables host cell surface receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adhesion of symbiont to microvasculature IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within antigenic variation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont-mediated perturbation of host erythrocyte aggregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Maurer's cleft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in host cell plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in symbiont-containing vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rifin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037284.1 Reference assembly

      Range
      2228632..2229740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350895.1 → XP_001350931.1  rifin [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350931.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2I0BY11, Q8I4N9, W7JQX9
      Conserved Domains (1) summary
      PTZ00046
      Location:1 → 317
      PTZ00046; rifin; Provisional
    Nucleotide Protein
    Heading Accession and Version

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