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    OR2T7 olfactory receptor family 2 subfamily T member 7 (gene/pseudogene) [ Homo sapiens (human) ]

    Gene ID: 81458, updated on 4-Jan-2025

    Summary

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    Official Symbol
    OR2T7provided by HGNC
    Official Full Name
    olfactory receptor family 2 subfamily T member 7 (gene/pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:15019
    See related
    Ensembl:ENSG00000227152 AllianceGenome:HGNC:15019
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR2T7P; OST723
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
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    Genomic context

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    See OR2T7 in Genome Data Viewer
    Location:
    1q44
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248436359..248444316)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (247880982..247888943)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (248599660..248607617)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily T member 6 Neighboring gene MPRA-validated peak838 silencer Neighboring gene olfactory receptor family 2 subfamily T member 1 Neighboring gene MPRA-validated peak839 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:248616387-248616588 Neighboring gene olfactory receptor family 2 subfamily T member 2 Neighboring gene uncharacterized LOC105373279 Neighboring gene olfactory receptor family 2 subfamily T member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. Barnes IHA, et al. BMC Genomics, 2020 Mar 3. PMID 32126975, Free PMC Article
    2. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
    3. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
    4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 2T7
    Names
    olfactory receptor OR1-44
    olfactory receptor, family 2, subfamily T, member 7 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386051.2 → NP_001372980.2  olfactory receptor 2T7 isoform 1

      Status: INFERRED

      Description
      Transcript Variant: This variant (1, coding) represents the protein-coding allele encoded by the T2T-CHM13v2.0 genome assembly.
      Source sequence(s)
      CP068277
      UniProtKB/TrEMBL
      A0AAG2UVJ4
      Conserved Domains (1) summary
      cd15421
      Location:26 → 301
      7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RNA

    1. NR_172522.1 RNA Sequence

      Status: INFERRED

      Description
      Transcript Variant: This variant (1, non-coding) uses the same exon combination as variant 1, coding, but represents the allele encoded by the GRCh38 reference assembly. This variant is represented as non-coding because a frameshift in the N-terminus results in a premature stop codon.
      Source sequence(s)
      AC138089
      Related
      ENST00000641557.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      248436359..248444316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791755.1 Reference GRCh38.p14 PATCHES

      Range
      84333..92290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187518.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      90399..98356
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      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187646.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      86777..94734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      247880982..247888943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_004272.4: Suppressed sequence

      Description
      NG_004272.4: This RefSeq was removed because it is now thought that this locus is a transcribed gene.

    2. NM_001355223.1: Suppressed sequence

      Description
      NM_001355223.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

    3. NM_001386052.1: Suppressed sequence

      Description
      NM_001386052.1: This RefSeq was removed because it is now thought that this gene is a pseudogene on the reference assembly GRCh38.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C7T2.1 GenPept UniProtKB/Swiss-Prot:P0C7T2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials