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    Chrm2 cholinergic receptor, muscarinic 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81645, updated on 9-Dec-2024

    Summary

    Symbol
    Chrm2provided by RGD
    Full Name
    cholinergic receptor, muscarinic 2provided by RGD
    Primary source
    RGD:620023
    See related
    EnsemblRapid:ENSRNOG00000046972 AllianceGenome:RGD:620023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Acm2
    Summary
    Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway and regulation of smooth muscle contraction. Located in several cellular components, including asymmetric synapse; neuronal cell body; and symmetric synapse. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; bipolar disorder; heroin dependence; major depressive disorder; and schizophrenia. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See Chrm2 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (65981136..66116128)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (65015408..65149104)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (64089028..64091090)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RHEB like 1, pseudogene 1 Neighboring gene uncharacterized LOC102554507 Neighboring gene U2 spliceosomal RNA Neighboring gene microRNA 490 Neighboring gene pleiotrophin Neighboring gene diacylglycerol kinase, iota

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled acetylcholine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables arrestin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in asymmetric synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in symmetric synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    muscarinic acetylcholine receptor M2
    Names
    7TM receptor
    M2 muscarinic acetylcholine receptor
    cholinergic receptor, muscarinic 2, cardiac
    muscarinic acetylcholine receptor M2-like
    muscarinic receptor m2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031016.2NP_112278.2  muscarinic acetylcholine receptor M2

      Status: VALIDATED

      Source sequence(s)
      AY571965, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P10980, Q9Z2Z1
      UniProtKB/TrEMBL
      A6IEP6
      Related
      ENSRNOP00000065178.1, ENSRNOT00000075341.4
      Conserved Domains (1) summary
      cd15297
      Location:24451
      7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      65981136..66116128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286746.1XP_063142816.1  muscarinic acetylcholine receptor M2 isoform X1

      UniProtKB/Swiss-Prot
      P10980, Q9Z2Z1
      UniProtKB/TrEMBL
      A6IEP6
      Related
      ENSRNOP00000082007.1, ENSRNOT00000115807.2
    2. XM_039108421.2XP_038964349.1  muscarinic acetylcholine receptor M2 isoform X1

      UniProtKB/Swiss-Prot
      P10980, Q9Z2Z1
      UniProtKB/TrEMBL
      A6IEP6
      Conserved Domains (1) summary
      cd15297
      Location:24451
      7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors