Renbp renin binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Renbpprovided by RGD
Official Full Name: renin binding proteinprovided by RGD
Primary source: RGD:621688
See related: EnsemblRapid:ENSRNOG00000054765 AllianceGenome:RGD:621688
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including ATP binding activity; N-acylglucosamine 2-epimerase activity; and identical protein binding activity. Involved in N-acetylglucosamine metabolic process; N-acetylmannosamine metabolic process; and negative regulation of endopeptidase activity. Orthologous to human RENBP (renin binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 165.1), Adrenal (RPKM 78.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (156812785..156821860, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (151661463..151670538, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (156854490..156863548)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The gene encoding renin binding protein (Renbp) has been assigned to rat chromosome Xq37.
Title: Assignment of the gene encoding renin binding protein (Renbp) to rat chromosome Xq37 by in situ hybridization and radiation hybrid mapping.
domain structure of renin binding protein
Title: Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein).

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables N-acylglucosamine 2-epimerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acylglucosamine 2-epimerase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acylglucosamine 2-epimerase activity	IEA Inferred from Electronic Annotation more info
enables N-acylglucosamine 2-epimerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables N-acylglucosamine 2-epimerase activity	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables peptidase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables purine nucleotide binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acetylglucosamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within N-acetylglucosamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in N-acetylmannosamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acetylmannosamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in N-acetylneuraminate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: N-acylglucosamine 2-epimerase

Names: AGE; N-acetyl-D-glucosamine 2-epimerase; glcNAc 2-epimerase; rnBP

NP_112357.1

EC 5.1.3.8

XP_038956018.1

EC 5.1.3.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031095.1 → NP_112357.1 N-acylglucosamine 2-epimerase

See identical proteins and their annotated locations for NP_112357.1

Status: PROVISIONAL

Source sequence(s)

D10233

UniProtKB/Swiss-Prot

P51607

UniProtKB/TrEMBL

A0A8Z7NAG7, A6KRT2

Related

ENSRNOP00000104970.1, ENSRNOT00000161110.1

Conserved Domains (1) summary

cd00249
Location:4 → 397

AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

156812785..156821860 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039100090.2 → XP_038956018.1 N-acylglucosamine 2-epimerase isoform X1

UniProtKB/TrEMBL

A0A8I5XWW6

Related

ENSRNOP00000078204.2, ENSRNOT00000108606.2

Conserved Domains (1) summary

cd00249
Location:15 → 361

AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...