U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ANGPTL6 angiopoietin like 6 [ Homo sapiens (human) ]

    Gene ID: 83854, updated on 10-Dec-2024

    Summary

    Official Symbol
    ANGPTL6provided by HGNC
    Official Full Name
    angiopoietin like 6provided by HGNC
    Primary source
    HGNC:HGNC:23140
    See related
    Ensembl:ENSG00000130812 MIM:609336; AllianceGenome:HGNC:23140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AGF; ARP5
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in angiogenesis and cell differentiation. Located in collagen-containing extracellular matrix and extracellular exosome. Biomarker of gestational diabetes. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver (RPKM 8.2), spleen (RPKM 5.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ANGPTL6 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10092338..10106190, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10218556..10232399, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10203014..10216866, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene microRNA 5589 Neighboring gene complement component 3 precursor pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10185500-10185601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10052 Neighboring gene shiftless antiviral inhibitor of ribosomal frameshifting Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13937 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10216675-10217318 Neighboring gene PPAN-P2RY11 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10218607-10219250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10220162-10220743 Neighboring gene small nucleolar RNA, C/D box 105 Neighboring gene small nucleolar RNA, C/D box 105B Neighboring gene peter pan homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    EBI GWAS Catalog
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    angiopoietin-related protein 6
    Names
    angiopoietin-like protein 6
    angiopoietin-related growth factor
    angiopoietin-related protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321411.2NP_001308340.1  angiopoietin-related protein 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC020931
      Consensus CDS
      CCDS12224.1
      UniProtKB/Swiss-Prot
      A5PKV7, Q8NI99, Q9BZZ0
      UniProtKB/TrEMBL
      K7EKF6
      Related
      ENSP00000467930.1, ENST00000592641.5
      Conserved Domains (1) summary
      cd00087
      Location:255468
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    2. NM_001387347.1NP_001374276.1  angiopoietin-related protein 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC020931
      Consensus CDS
      CCDS12224.1
      UniProtKB/Swiss-Prot
      A5PKV7, Q8NI99, Q9BZZ0
      UniProtKB/TrEMBL
      K7EKF6
      Conserved Domains (1) summary
      cd00087
      Location:255468
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    3. NM_001387348.1NP_001374277.1  angiopoietin-related protein 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC020931
      Consensus CDS
      CCDS12224.1
      UniProtKB/Swiss-Prot
      A5PKV7, Q8NI99, Q9BZZ0
      UniProtKB/TrEMBL
      K7EKF6
      Conserved Domains (1) summary
      cd00087
      Location:255468
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    4. NM_031917.3NP_114123.2  angiopoietin-related protein 6 precursor

      See identical proteins and their annotated locations for NP_114123.2

      Status: VALIDATED

      Source sequence(s)
      AC020931
      Consensus CDS
      CCDS12224.1
      UniProtKB/Swiss-Prot
      A5PKV7, Q8NI99, Q9BZZ0
      UniProtKB/TrEMBL
      K7EKF6
      Related
      ENSP00000253109.3, ENST00000253109.5
      Conserved Domains (1) summary
      cd00087
      Location:255468
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10092338..10106190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528349.4XP_011526651.1  angiopoietin-related protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011526651.1

      UniProtKB/TrEMBL
      K7EKF6
      Conserved Domains (1) summary
      cd00087
      Location:322535
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    2. XM_011528348.4XP_011526650.1  angiopoietin-related protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011526650.1

      UniProtKB/TrEMBL
      K7EKF6
      Conserved Domains (1) summary
      cd00087
      Location:322535
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      10218556..10232399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322299.1XP_054178274.1  angiopoietin-related protein 6 isoform X1

      UniProtKB/TrEMBL
      K7EKF6
    2. XM_054322298.1XP_054178273.1  angiopoietin-related protein 6 isoform X1

      UniProtKB/TrEMBL
      K7EKF6