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    IAR3 peptidase M20/M25/M40 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841602, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IAR3
    Official Full Name
    peptidase M20/M25/M40 family protein
    Primary source
    TAIR:AT1G51760
    Locus tag
    AT1G51760
    See related
    Araport:AT1G51760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F19C24.4; F19C24_4; IAA-ALA HYDROLASE; IAA-ALANINE RESISTANT 3; JASMONIC ACID RESPONSIVE 3; JR3
    Summary
    encodes a member of the six Arabidopsis IAA-amino acid conjugate hydrolase subfamily and conjugates and conjugates IAA-Ala in vitro. Gene is expressed most strongly in roots, stems, and flowers.
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    Genomic context

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    See IAR3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (19199351..19201707)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Tudor/PWWP/MBT superfamily protein Neighboring gene pseudo Neighboring gene Core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein Neighboring gene IAA-amino acid hydrolase ILR1-like 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Role of Cysteine Residues in Redox Regulation and Protein Stability of Arabidopsis thaliana Starch Synthase 1. Skryhan K, et al. PLoS One, 2015. PMID 26367870, Free PMC Article
    2. IAA-Ala Resistant3, an evolutionarily conserved target of miR167, mediates Arabidopsis root architecture changes during high osmotic stress. Kinoshita N, et al. Plant Cell, 2012 Sep. PMID 22960911, Free PMC Article
    3. The amidohydrolases IAR3 and ILL6 contribute to jasmonoyl-isoleucine hormone turnover and generate 12-hydroxyjasmonic acid upon wounding in Arabidopsis leaves. Widemann E, et al. J Biol Chem, 2013 Nov 1. PMID 24052260, Free PMC Article
    4. IAR3 encodes an auxin conjugate hydrolase from Arabidopsis. Davies RT, et al. Plant Cell, 1999 Mar. PMID 10072397, Free PMC Article
    5. A downstream mediator in the growth repression limb of the jasmonate pathway. Yan Y, et al. Plant Cell, 2007 Aug. PMID 17675405, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest distinct physiological roles of redox-active Cys residues in AtSS1 including diurnal activity regulation directly linked to photosynthesis as well as stress-related protection of AtSS1.
      Title: The Role of Cysteine Residues in Redox Regulation and Protein Stability of Arabidopsis thaliana Starch Synthase 1.
    2. The amidohydrolases IAR3 and ILL6 contribute to jasmonoyl-isoleucine hormone turnover and generate 12-hydroxyjasmonic acid upon wounding in Arabidopsis leaves.
      Title: The amidohydrolases IAR3 and ILL6 contribute to jasmonoyl-isoleucine hormone turnover and generate 12-hydroxyjasmonic acid upon wounding in Arabidopsis leaves.
    3. IAR3 is a regulator of root architecture changes in osmotic stress and drought tolerance.
      Title: IAA-Ala Resistant3, an evolutionarily conserved target of miR167, mediates Arabidopsis root architecture changes during high osmotic stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_104055.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables IAA-Ala conjugate hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in auxin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    peptidase M20/M25/M40 family protein
    NP_175587.1
    • IAA-ALANINE RESISTANT 3 (IAR3); FUNCTIONS IN: metallopeptidase activity, IAA-Ala conjugate hydrolase activity; INVOLVED IN: proteolysis, response to wounding; LOCATED IN: endoplasmic reticulum, plasma membrane; EXPRESSED IN: callus; CONTAINS InterPro DOMAIN/s: Peptidase M20 (InterPro:IPR002933), Peptidase M20D, mername-AA028/carboxypeptidase Ss1 (InterPro:IPR017439), Peptidase M20, dimerisation (InterPro:IPR011650), Peptidase M20D, amidohydrolase (InterPro:IPR010168); BEST Arabidopsis thaliana protein match is: IAA-leucine resistant (ILR)-like gene 5 (TAIR:AT1G51780.1); Has 13368 Blast hits to 13360 proteins in 1987 species: Archae - 133; Bacteria - 9793; Metazoa - 95; Fungi - 261; Plants - 323; Viruses - 0; Other Eukaryotes - 2763 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19199351..19201707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104055.4 → NP_175587.1  peptidase M20/M25/M40 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175587.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04373, O81642
      UniProtKB/TrEMBL
      A0A178W8I8, A0A5S9WNW0
      Conserved Domains (1) summary
      cd08017
      Location:48 → 423
      M20_IAA_Hyd; M20 Peptidase Indole-3-acetic acid amino acid hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04373.2

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