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    RBL2 RHOMBOID-like 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842616, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RBL2
    Official Full Name
    RHOMBOID-like 2
    Primary source
    TAIR:AT1G63120
    Locus tag
    AT1G63120
    See related
    Araport:AT1G63120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRBL2; F16M19.4; F16M19_4; RHOMBOID-like 2
    Summary
    AtRBL2 has been identified as a rhomboid protein involved in regulated intramembrane proteolysis (RIP). The enzyme has the proteolytic activity and substrate specificity comparable to the Drosophila Rho-1 protein.
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    Genomic context

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    See RBL2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (23408804..23411139, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene GPI transamidase subunit PIG-U Neighboring gene miscRNA Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic reticulum-bound ANAC013 factor is cleaved by RHOMBOID-LIKE 2 during the initial response to hypoxia in Arabidopsis thaliana. Eysholdt-Derzsó E, et al. Proc Natl Acad Sci U S A, 2023 Mar 14. PMID 36897975, Free PMC Article
    2. An Arabidopsis Rhomboid homolog is an intramembrane protease in plants. Kanaoka MM, et al. FEBS Lett, 2005 Oct 24. PMID 16223493
    3. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article
    4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endoplasmic reticulum-bound ANAC013 factor is cleaved by RHOMBOID-LIKE 2 during the initial response to hypoxia in Arabidopsis thaliana.
      Title: Endoplasmic reticulum-bound ANAC013 factor is cleaved by RHOMBOID-LIKE 2 during the initial response to hypoxia in Arabidopsis thaliana.
    2. Arabidopsis Rhomboid protein AtRBL2 has proteolytic activity and substrate specificity. [AtRBL2]
      Title: An Arabidopsis Rhomboid homolog is an intramembrane protease in plants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_104990.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    RHOMBOID-like 2
    NP_176500.1
    • RHOMBOID-like 2 (RBL2); CONTAINS InterPro DOMAIN/s: Peptidase S54, rhomboid (InterPro:IPR002610); BEST Arabidopsis thaliana protein match is: RHOMBOID-like protein 6 (TAIR:AT1G12750.3); Has 6856 Blast hits to 6855 proteins in 1947 species: Archae - 152; Bacteria - 4411; Metazoa - 521; Fungi - 179; Plants - 374; Viruses - 0; Other Eukaryotes - 1219 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      23408804..23411139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104990.4 → NP_176500.1  RHOMBOID-like 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176500.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9CAN1
      UniProtKB/TrEMBL
      A0A178WK17
      Conserved Domains (1) summary
      pfam01694
      Location:105 → 244
      Rhomboid; Rhomboid family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CAN1.1

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