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    SEC22 SNAP receptor SEC22 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850973, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEC22
    Official Full Name
    SNAP receptor SEC22
    Primary source
    SGD:S000004258
    Locus tag
    YLR268W
    See related
    AllianceGenome:SGD:S000004258; FungiDB:YLR268W; VEuPathDB:YLR268W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SLY2; TS26; TSL26
    Summary
    Enables SNAP receptor activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; and vesicle fusion with Golgi apparatus. Located in ER to Golgi transport vesicle membrane; Golgi apparatus; and endoplasmic reticulum. Part of SNARE complex. Orthologous to human SEC22B (SEC22 homolog B, vesicle trafficking protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEC22 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (680200..680844)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Pdr8p Neighboring gene Bop2p Neighboring gene 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase Neighboring gene Cmg1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Derf A, et al. Bioorg Med Chem Lett, 2019 Feb 1. PMID 30579794
    2. Isolation, DNA sequence and regulation of a new cell division cycle gene from the yeast Saccharomyces cerevisiae. Hasegawa H, et al. Yeast, 1989 Nov-Dec. PMID 2694679
    3. Bos1p, an integral membrane protein of the endoplasmic reticulum to Golgi transport vesicles, is required for their fusion competence. Lian JP, et al. Cell, 1993 May 21. PMID 8500167
    4. Analysis of Sec22p in endoplasmic reticulum/Golgi transport reveals cellular redundancy in SNARE protein function. Liu Y, et al. Mol Biol Cell, 2002 Sep. PMID 12221135, Free PMC Article
    5. Ypt1p implicated in v-SNARE activation. Lian JP, et al. Nature, 1994 Dec 15. PMID 7990964

    See all (177) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNAP receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle fusion with Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion with Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ER to Golgi transport vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SNARE complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bounding membrane of organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SNAP receptor SEC22
    NP_013370.1
    • R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      680200..680844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182155.1 → NP_013370.1  TPA: SNAP receptor SEC22 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013370.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYR6, P22214
      UniProtKB/TrEMBL
      A7A1F0, B3RHF2, B5VNI0, C7GQX2, C8ZDN3, G2WJ94, N1NYH7
      Conserved Domains (1) summary
      COG5143
      Location:2 → 192
      SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22214.1

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