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    GAS2 1,3-beta-glucanosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851056, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GAS2
    Official Full Name
    1,3-beta-glucanosyltransferase
    Primary source
    SGD:S000004335
    Locus tag
    YLR343W
    See related
    AllianceGenome:SGD:S000004335; FungiDB:YLR343W; VEuPathDB:YLR343W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 1,3-beta-glucanosyltransferase activity. Involved in ascospore wall assembly and fungal-type cell wall beta-glucan biosynthetic process. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GAS2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (816094..817761)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene 1,3-beta-D-glucan synthase Neighboring gene uncharacterized protein Neighboring gene tRNA-Arg Neighboring gene ribosomal 60S subunit protein L26A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanisms of yeast cell wall glucan remodeling. Hurtado-Guerrero R, et al. J Biol Chem, 2009 Mar 27. PMID 19097997, Free PMC Article
    2. A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations. Raich L, et al. J Am Chem Soc, 2016 Mar 16. PMID 26859322
    3. Disulfide bond structure and domain organization of yeast beta(1,3)-glucanosyltransferases involved in cell wall biogenesis. Popolo L, et al. J Biol Chem, 2008 Jul 4. PMID 18468997
    4. GAS2 and GAS4, a pair of developmentally regulated genes required for spore wall assembly in Saccharomyces cerevisiae. Ragni E, et al. Eukaryot Cell, 2007 Feb. PMID 17189486, Free PMC Article
    5. Expression, stability, and replacement of glucan-remodeling enzymes during developmental transitions in Saccharomyces cerevisiae. Rolli E, et al. Mol Biol Cell, 2011 May. PMID 21389112, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1,3-beta-glucanosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1,3-beta-glucanosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucanosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore wall assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall beta-glucan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization or biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1,3-beta-glucanosyltransferase
    NP_013447.1
    • 1,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      816094..817761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182232.1 → NP_013447.1  TPA: 1,3-beta-glucanosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013447.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYY2, Q06135
      UniProtKB/TrEMBL
      G2WJG2, N1P1N2
      Conserved Domains (2) summary
      pfam03198
      Location:25 → 344
      Glyco_hydro_72; Glucanosyltransferase
      pfam07983
      Location:397 → 473
      X8; X8 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06135.1

    Gene LinkOut

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