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    MAP2 methionine aminopeptidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852187, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MAP2
    Official Full Name
    methionine aminopeptidase
    Primary source
    SGD:S000000187
    Locus tag
    YBL091C
    See related
    AllianceGenome:SGD:S000000187; FungiDB:YBL091C; VEuPathDB:YBL091C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables metalloaminopeptidase activity. Involved in protein maturation. Located in cytoplasm and nucleus. Orthologous to human METAP2 (methionyl aminopeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MAP2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (47363..48628, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L32 Neighboring gene phospholipid metabolism-regulating protein SCS22 Neighboring gene mitochondrial 37S ribosomal protein MRP21 Neighboring gene amino acid transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amino-terminal protein processing in Saccharomyces cerevisiae is an essential function that requires two distinct methionine aminopeptidases. Li X, et al. Proc Natl Acad Sci U S A, 1995 Dec 19. PMID 8618900, Free PMC Article
    2. A dominant negative mutation in Saccharomyces cerevisiae methionine aminopeptidase-1 affects catalysis and interferes with the function of methionine aminopeptidase-2. Klinkenberg M, et al. Arch Biochem Biophys, 1997 Nov 15. PMID 9367524
    3. The specificity in vivo of two distinct methionine aminopeptidases in Saccharomyces cerevisiae. Chen S, et al. Arch Biochem Biophys, 2002 Feb 1. PMID 11811952
    4. A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases. Brdlik CM, et al. J Biol Chem, 2004 Mar 5. PMID 14676204, Free PMC Article
    5. Type I methionine aminopeptidase from Saccharomyces cerevisiae is a potential target for antifungal drug screening. Chen LL, et al. Acta Pharmacol Sin, 2004 Jul. PMID 15210064

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables initiator methionyl aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables metalloexopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    methionine aminopeptidase
    NP_009462.2
    • Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      47363..48628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178331.2 → NP_009462.2  TPA: methionine aminopeptidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009462.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZKL2, B3LNM2, B5VDQ0, C7GSF3, C8Z3V4, D6VPR3, P38174, P89493
      UniProtKB/TrEMBL
      G2W8S2, N1P8A6
      Conserved Domains (1) summary
      PTZ00053
      Location:58 → 421
      PTZ00053; methionine aminopeptidase 2; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38174.4

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