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    ETR1 enoyl-[acyl-carrier-protein] reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852314, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ETR1
    Official Full Name
    enoyl-[acyl-carrier-protein] reductase
    Primary source
    SGD:S000000230
    Locus tag
    YBR026C
    See related
    AllianceGenome:SGD:S000000230; FungiDB:YBR026C; VEuPathDB:YBR026C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MRF1; MRF1'
    Summary
    Predicted to enable DNA binding activity and enoyl-[acyl-carrier-protein] reductase (NADPH) activity. Involved in aerobic respiration and fatty acid biosynthetic process. Located in mitochondrion. Used to study Leber hereditary optic neuropathy with demyelinating disease of CNS. Human ortholog(s) of this gene implicated in childhood-onset dystonia with optic atrophy and basal ganglia abnormalities and optic atrophy. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ETR1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (292877..294019, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene putative thioredoxin peroxidase SCO2 Neighboring gene Obg-like ATPase Neighboring gene uncharacterized protein Neighboring gene putative protein kinase YPK3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A protein which binds preferentially to single-stranded core sequence of autonomously replicating sequence is essential for respiratory function in mitochondrial of Saccharomyces cerevisiae. Yamazoe M, et al. J Biol Chem, 1994 May 27. PMID 8195160
    2. Candida tropicalis Etr1p and Saccharomyces cerevisiae Ybr026p (Mrf1'p), 2-enoyl thioester reductases essential for mitochondrial respiratory competence. Torkko JM, et al. Mol Cell Biol, 2001 Sep. PMID 11509667, Free PMC Article
    3. Structure-function analysis of enoyl thioester reductase involved in mitochondrial maintenance. Airenne TT, et al. J Mol Biol, 2003 Mar 14. PMID 12614607
    4. Function of heterologous Mycobacterium tuberculosis InhA, a type 2 fatty acid synthase enzyme involved in extending C20 fatty acids to C60-to-C90 mycolic acids, during de novo lipoic acid synthesis in Saccharomyces cerevisiae. Gurvitz A, et al. Appl Environ Microbiol, 2008 Aug. PMID 18552191, Free PMC Article
    5. ZAP1-mediated modulation of triacylglycerol levels in yeast by transcriptional control of mitochondrial fatty acid biosynthesis. Singh N, et al. Mol Microbiol, 2016 Apr. PMID 26711224

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adr1 influenced the transcription levels of ETR1, but it did not alter the abundance of Etr1 protein.
      Title: A novel circuit overrides Adr1p control during expression of Saccharomyces cerevisiae 2-trans-enoyl-ACP reductase Etr1p of mitochondrial type 2 fatty acid synthase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    enoyl-[acyl-carrier-protein] reductase
    NP_009582.1
    • 2-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to mitochondria, where it has a probable role in fatty acid synthesis; human MECR functionally complements the respiratory growth defect of the null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      292877..294019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178374.1 → NP_009582.1  TPA: enoyl-[acyl-carrier-protein] reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009582.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ28, P38071, Q6Q5P2
      UniProtKB/TrEMBL
      A6ZKX2, B3LNB7, C7GM26, C8Z420, G2W933
      Conserved Domains (1) summary
      cd08290
      Location:21 → 345
      ETR; 2-enoyl thioester reductase (ETR)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38071.3

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