Xpo1 exportin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Xpo1provided by RGD
Official Full Name: exportin 1provided by RGD
Primary source: RGD:620517
See related: EnsemblRapid:ENSRNOG00000009935 AllianceGenome:RGD:620517
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: exp1
Summary: Enables DNA-binding transcription factor binding activity and protein domain specific binding activity. Involved in several processes, including cellular response to salt; cellular response to triglyceride; and protein export from nucleus. Predicted to be located in several cellular components, including annulate lamellae; kinetochore; and nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 342.2), Spleen (RPKM 314.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (101434450..101476705)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (97233282..97275536)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (108007421..108049088)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that the cancer-inhibitory activity of sodium butyrate and its derivatives on liver carcinogenesis may be attributed to retention of p53 and CRM1 proteins in the nucleus, an event that may trigger activation of p53-mediated apoptotic cell death in neoplastic cells.
Title: Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.
CRM1 mRNA and protein expression in cortical neurons is upregulated after traumatic brin injury.
Title: Upregulation of CRM1 relates to neuronal apoptosis after traumatic brain injury in adult rats.
Our results suggest that CRM 1-dependent NES-mediated mechanisms influence the degradation and agonist-mediated down-regulation of the beta1-AR mRNAs.
Title: CRM 1-mediated degradation and agonist-induced down-regulation of beta-adrenergic receptor mRNAs.
the mechanism underlying the function of human and rat CRM1 in HIV-1 replication was investigated in rat cells.
Title: Nuclear and cytoplasmic effects of human CRM1 on HIV-1 production in rat cells.
Phosphorylation of ChREBP was essential for its interaction with CRM1 for export to the cytosol, whereas nuclear import of ChREBP requires dephosphorylated ChREBP to interact with importin alpha.
Title: Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation.
exportin 1 controls pathological cardiac gene expression.
Title: The CRM1 nuclear export receptor controls pathological cardiac gene expression.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Xpo1 (e-PCR), detects polymorphism
- UniSTS:498285

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nuclear export signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear export signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear export signal receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to salt	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to triglyceride	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleocytoplasmic transport	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein export from nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of centrosome duplication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein export from nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in ribosomal large subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in ribosomal small subunit export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in ribosomal subunit export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in ribosome biogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Cajal body	IEA Inferred from Electronic Annotation more info
located_in annulate lamellae	IEA Inferred from Electronic Annotation more info
located_in annulate lamellae	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: exportin-1

Names: chromosome region maintenance 1 protein homolog; exportin 1 (CRM1, yeast, homolog); exportin 1, CRM1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053490.2 → NP_445942.1 exportin-1

See identical proteins and their annotated locations for NP_445942.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q80U96

UniProtKB/TrEMBL

A0A8I6AT26, A6JQ67

Related

ENSRNOP00000087052.2, ENSRNOT00000101915.2

Conserved Domains (1) summary

COG5101
Location:15 → 1044

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]