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    SCS3 Scs3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852751, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SCS3
    Official Full Name
    Scs3p
    Primary source
    SGD:S000003094
    Locus tag
    YGL126W
    See related
    AllianceGenome:SGD:S000003094; FungiDB:YGL126W; VEuPathDB:YGL126W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FIT2B
    Summary
    Predicted to enable coenzyme A diphosphatase activity. Involved in phospholipid biosynthetic process. Acts upstream of or within phospholipid homeostasis. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to human FITM1 (fat storage inducing transmembrane protein 1) and FITM2 (fat storage inducing transmembrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SCS3 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (270997..272139)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene U2-type spliceosomal complex subunit CWC23 Neighboring gene mediator complex subunit SOH1 Neighboring gene methylenetetrahydrofolate reductase (NAD(P)H) MET13 Neighboring gene Mon1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequence of the SCS3 gene which is required for inositol prototrophy in Saccharomyces cerevisiae. Hosaka K, et al. J Biochem, 1994 Dec. PMID 7706223
    2. SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR. Moir RD, et al. PLoS Genet, 2012 Aug. PMID 22927826, Free PMC Article
    3. Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferase enzymes. Hayes M, et al. Microb Cell, 2017 Dec 28. PMID 29417057, Free PMC Article
    4. FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. Becuwe M, et al. J Cell Biol, 2020 Oct 5. PMID 32915949, Free PMC Article
    5. The surface of lipid droplets constitutes a barrier for endoplasmic reticulum-resident integral membrane proteins. Khaddaj R, et al. J Cell Sci, 2022 Mar 1. PMID 34028531

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis.
      Title: FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis.
    2. Study shows that SCS3 and YFT2 have shared and unique functions that connect major biosynthetic processes critical for cell growth.
      Title: SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables coenzyme A diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coenzyme A diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty-acyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in lipid droplet formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid droplet organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid storage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Scs3p
    NP_011389.3
    • Protein required for normal ER membrane biosynthesis in response to ER stress; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; human homolog FIT2/FITM2, a fatty acyl-CoA diphosphatase, complements the yeast null mutant; disputed role in the synthesis of inositol phospholipids from inositol; required for inositol prototrophy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      270997..272139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180991.3 → NP_011389.3  TPA: Scs3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011389.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU22, E9P8W2, P53012
      UniProtKB/TrEMBL
      A6ZU56, B3LHI6, C7GX61, C8Z8C4, N1P3F4
      Conserved Domains (1) summary
      pfam10261
      Location:38 → 370
      Scs3p; Inositol phospholipid synthesis and fat-storage-inducing TM
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53012.1

    Gene LinkOut

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