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    CYS4 cystathionine beta-synthase CYS4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853059, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CYS4
    Official Full Name
    cystathionine beta-synthase CYS4
    Primary source
    SGD:S000003387
    Locus tag
    YGR155W
    See related
    AllianceGenome:SGD:S000003387; FungiDB:YGR155W; VEuPathDB:YGR155W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NHS5; STR4; VMA41
    Summary
    Enables cystathionine beta-synthase activity. Involved in cysteine metabolic process; hydrogen sulfide biosynthetic process; and traversing start control point of mitotic cell cycle. Located in cytoplasmic stress granule and mitochondrion. Is active in cytoplasm. Used to study Down syndrome; breast cancer; colon cancer; homocystinuria; and ovarian cancer. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CYS4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (798543..800066)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene omega-class glutathione transferase Neighboring gene cleavage polyadenylation factor subunit PTI1 Neighboring gene phosphatidylethanolamine N-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and mapping of the CYS4 gene of Saccharomyces cerevisiae. Ono B, et al. Curr Genet, 1992 Apr. PMID 1525856
    2. Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases. Majtan T, et al. PLoS One, 2014. PMID 25122507, Free PMC Article
    3. Purification, crystallization and preliminary crystallographic analysis of the catalytic core of cystathionine β-synthase from Saccharomyces cerevisiae. Ereño-Orbea J, et al. Acta Crystallogr F Struct Biol Commun, 2014 Mar. PMID 24598918, Free PMC Article
    4. Converging evidence of mitochondrial dysfunction in a yeast model of homocysteine metabolism imbalance. Kumar A, et al. J Biol Chem, 2011 Jun 17. PMID 21504896, Free PMC Article
    5. Pre-steady-state kinetic analysis of enzyme-monitored turnover during cystathionine β-synthase-catalyzed H(2)S generation. Singh S, et al. Biochemistry, 2011 Jan 25. PMID 21141970, Free PMC Article

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cystathionine beta-synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cystathionine beta-synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cystathionine beta-synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cystathionine beta-synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteine biosynthetic process from serine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteine biosynthetic process from serine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cysteine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteine biosynthetic process via cystathionine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteine biosynthetic process via cystathionine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cysteine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hydrogen sulfide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in serine family amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfur compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transsulfuration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in traversing start control point of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    cystathionine beta-synthase CYS4
    NP_011671.3
    • Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      798543..800066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181284.3 → NP_011671.3  TPA: cystathionine beta-synthase CYS4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011671.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUT5, P32582, Q05177, Q27JK1, Q27JK4
      UniProtKB/TrEMBL
      A6ZUG6, B3LI75, B5VJ98, C7GQ63, C8Z949, G2WEN5, N1P5Z1
      Conserved Domains (1) summary
      TIGR01137
      Location:10 → 507
      cysta_beta; cystathionine beta-synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32582.1

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