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    ERV29 Erv29p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853201, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERV29
    Official Full Name
    Erv29p
    Primary source
    SGD:S000003516
    Locus tag
    YGR284C
    See related
    AllianceGenome:SGD:S000003516; FungiDB:YGR284C; VEuPathDB:YGR284C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables COPII receptor activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in COPII-coated ER to Golgi transport vesicle. Orthologous to human SURF4 (surfeit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ERV29 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1060658..1061590, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene glucan 1,3-beta-glucosidase Neighboring gene putative methyltransferase Neighboring gene zuotin Neighboring gene biotin synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane topology of the endoplasmic reticulum to Golgi transport factor Erv29p. Foley DA, et al. Mol Membr Biol, 2007 Jul-Aug. PMID 17520482
    2. Role of Erv29p in collecting soluble secretory proteins into ER-derived transport vesicles. Belden WJ, et al. Science, 2001 Nov 16. PMID 11711675
    3. Sorting signals can direct receptor-mediated export of soluble proteins into COPII vesicles. Otte S, et al. Nat Cell Biol, 2004 Dec. PMID 15516922
    4. Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum. Yin Y, et al. PLoS Biol, 2018 Aug. PMID 30086131, Free PMC Article
    5. Sec16 function in ER export and autophagy is independent of its phosphorylation in Saccharomyces cerevisiae. Yorimitsu T, et al. Mol Biol Cell, 2020 Feb 1. PMID 31851588, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Surf4 (or its yeast ortholog, Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum.
      Title: Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum.
    2. Erv29p contains four transmembrane domains with both termini exposed to the cytosol. Two luminal loops may contain a recognition site for hydrophobic export signals on soluble cargo
      Title: Membrane topology of the endoplasmic reticulum to Golgi transport factor Erv29p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables COPII receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Erv29p
    NP_011800.3
    • Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1060658..1061590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181413.3 → NP_011800.3  TPA: Erv29p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011800.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV61, E9P8T4, P53337
      UniProtKB/TrEMBL
      A6ZUU0, B3LHW1, B5VJM8, C7GNF1, C8Z9H7, N1P2S5
      Conserved Domains (1) summary
      cl21527
      Location:48 → 310
      DoxX
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53337.1

    Gene LinkOut

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