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    ALD3 aldehyde dehydrogenase (NAD(+)) ALD3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855205, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ALD3
    Official Full Name
    aldehyde dehydrogenase (NAD(+)) ALD3
    Primary source
    SGD:S000004779
    Locus tag
    YMR169C
    See related
    AllianceGenome:SGD:S000004779; FungiDB:YMR169C; VEuPathDB:YMR169C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aldehyde dehydrogenase (NAD+) activity. Involved in beta-alanine biosynthetic process and polyamine catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to several human genes including ALDH1A1 (aldehyde dehydrogenase 1 family member A1); ALDH1A2 (aldehyde dehydrogenase 1 family member A2); and ALDH1A3 (aldehyde dehydrogenase 1 family member A3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ALD3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (599352..600872, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene mismatch repair ATPase MLH1 Neighboring gene Cep3p Neighboring gene aldehyde dehydrogenase (NAD(+)) ALD2 Neighboring gene Ear1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional, proteomic, and metabolic responses to lithium in galactose-grown yeast cells. Bro C, et al. J Biol Chem, 2003 Aug 22. PMID 12791685
    2. Upregulation of ALD3 and GPD1 in Saccharomyces cerevisiae during Icewine fermentation. Pigeau GM, et al. J Appl Microbiol, 2005. PMID 15960671
    3. In Vivo-In Vitro Comparative Toxicology of Cadmium Sulphide Quantum Dots in the Model Organism Saccharomyces cerevisiae. Pagano L, et al. Nanomaterials (Basel), 2019 Apr 2. PMID 30986968, Free PMC Article
    4. Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae. White WH, et al. Genetics, 2003 Jan. PMID 12586697, Free PMC Article
    5. Aberrant synthesis of indole-3-acetic acid in Saccharomyces cerevisiae triggers morphogenic transition, a virulence trait of pathogenic fungi. Rao RP, et al. Genetics, 2010 May. PMID 20233857, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-aminopropanal dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in beta-alanine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pantothenate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyamine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aldehyde dehydrogenase (NAD(+)) ALD3
    NP_013892.1
    • Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      599352..600872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182673.1 → NP_013892.1  TPA: aldehyde dehydrogenase (NAD(+)) ALD3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013892.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZZ1, P54114
      UniProtKB/TrEMBL
      A6ZMM8, B3LM56, G2WKM2
      Conserved Domains (1) summary
      cl11961
      Location:14 → 502
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54114.1

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