MET2 homoserine O-acetyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MET2
Official Full Name: homoserine O-acetyltransferase
Primary source: SGD:S000005221
Locus tag: YNL277W
See related: AllianceGenome:SGD:S000005221; FungiDB:YNL277W; VEuPathDB:YNL277W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables homoserine O-acetyltransferase activity. Involved in homoserine metabolic process and methionine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MET2 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (117349..118809)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reciprocal hemizygosity and allele swap experiments demonstrated that a mutant allele of the homoserine O-acetyltransferase-encoding MET2, confers reduced H2S production.
Title: MET2 affects production of hydrogen sulfide during wine fermentation.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables homoserine O-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables homoserine O-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables homoserine O-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables homoserine O-acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in homoserine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in homoserine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methionine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sulfur amino acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homoserine O-acetyltransferase

NP_014122.1

EC 2.3.1.31

L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

117349..118809

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183115.1 → NP_014122.1 TPA: homoserine O-acetyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014122.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0R8, P08465

UniProtKB/TrEMBL

A0A023VTP3, C8ZGP5, N1NZW3

Conserved Domains (1) summary

TIGR01392
Location:35 → 449

homoserO_Ac_trn; homoserine O-acetyltransferase