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    S-adenosylmethionine-dependent methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855632, updated on 9-Dec-2024

    Summary

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    Official Full Name
    S-adenosylmethionine-dependent methyltransferase
    Primary source
    SGD:S000005036
    Locus tag
    YNL092W
    See related
    AllianceGenome:SGD:S000005036; FungiDB:YNL092W; VEuPathDB:YNL092W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables S-adenosylmethionine-dependent methyltransferase activity. Involved in protein methylation. Orthologous to human CARNMT1 (carnosine N-methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (450871..452073)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene phosphatidate phosphatase APP1 Neighboring gene Rab family GTPase YPT53 Neighboring gene Nst1p Neighboring gene Rho family GTPase RHO2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Substrate Recognition Mechanism of the Putative Yeast Carnosine N-methyltransferase. Liu X, et al. ACS Chem Biol, 2017 Aug 18. PMID 28654751
    2. Probabilistic approach to predicting substrate specificity of methyltransferases. Szczepińska T, et al. PLoS Comput Biol, 2014 Mar. PMID 24651469, Free PMC Article
    3. Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects. Cheng CL, et al. Mol Biol Cell, 2021 Oct 1. PMID 34347506, Free PMC Article
    4. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
    5. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnosine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    S-adenosylmethionine-dependent methyltransferase
    NP_014307.1
    • S-adenosylmethionine-dependent protein methyltransferase; capable of automethylation; member of the seven beta-strand family; YNL092W is not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      450871..452073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182930.1 → NP_014307.1  TPA: S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014307.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W188, P53934, Q45TZ4
      UniProtKB/TrEMBL
      A0A0G3F7A4, B3LNV0, B5VQV1, C8ZGD9, N1P4F0
      Conserved Domains (1) summary
      pfam07942
      Location:88 → 396
      N2227; N2227-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53934.1

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