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    putative aminophospholipid translocase regulatory protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855784, updated on 9-Dec-2024

    Summary

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    Official Full Name
    putative aminophospholipid translocase regulatory protein
    Primary source
    SGD:S000005331
    Locus tag
    YNR048W
    See related
    AllianceGenome:SGD:S000005331; FungiDB:YNR048W; VEuPathDB:YNR048W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CRF1
    Summary
    Involved in phospholipid translocation. Located in trans-Golgi network. Orthologous to several human genes including TMEM30B (transmembrane protein 30B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (711630..712811)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene RNA methylation protein TRM112 Neighboring gene serine/threonine protein kinase FPK1 Neighboring gene Mso1p Neighboring gene saccharopine dehydrogenase (NADP+, L-glutamate-forming)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine. Hanson PK, et al. J Biol Chem, 2003 Sep 19. PMID 12842877
    2. Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico. Katoh Y, et al. Oncol Rep, 2004 Oct. PMID 15375526
    3. Cdc50p plays a vital role in the ATPase reaction cycle of the putative aminophospholipid transporter Drs2p. Lenoir G, et al. J Biol Chem, 2009 Jul 3. PMID 19411703, Free PMC Article
    4. The cloning and characterization of the CDC50 gene family in Saccharomyces cerevisiae. Radji M, et al. Yeast, 2001 Feb. PMID 11180453
    5. Cdc50p, a protein required for polarized growth, associates with the Drs2p P-type ATPase implicated in phospholipid translocation in Saccharomyces cerevisiae. Saito K, et al. Mol Biol Cell, 2004 Jul. PMID 15090616, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid translocation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative aminophospholipid translocase regulatory protein
    NP_014446.3
    • Potential noncatalytic subunit for phospholipid translocase Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      711630..712811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183225.3 → NP_014446.3  TPA: putative aminophospholipid translocase regulatory protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014446.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1M3, P53740
      UniProtKB/TrEMBL
      A6ZSC2, B3LPJ5, B5VR73, C7GLK9, C8ZFS7, G2WLA5, N1P4U7
      Conserved Domains (1) summary
      COG5035
      Location:3 → 375
      CDC50; Cell cycle control protein [Cell division and chromosome partitioning / Transcription / Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53740.1

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