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    ALD6 aldehyde dehydrogenase (NADP(+)) ALD6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856044, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ALD6
    Official Full Name
    aldehyde dehydrogenase (NADP(+)) ALD6
    Primary source
    SGD:S000005982
    Locus tag
    YPL061W
    See related
    AllianceGenome:SGD:S000005982; FungiDB:YPL061W; VEuPathDB:YPL061W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ALD1
    Summary
    Enables aldehyde dehydrogenase [NAD(P)+] activity. Involved in NADPH regeneration; acetate biosynthetic process; and response to salt stress. Located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to several human genes including ALDH1A1 (aldehyde dehydrogenase 1 family member A1); ALDH1A2 (aldehyde dehydrogenase 1 family member A2); and ALDH1A3 (aldehyde dehydrogenase 1 family member A3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ALD6 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (432588..434090)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene protein translocase subunit TIM50 Neighboring gene uncharacterized protein Neighboring gene Mfm1p Neighboring gene tRNA-Cys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Formaldehyde Treatment Using Overexpressed Aldehyde Dehydrogenase 6 from Recombinant Saccharomyces cerevisiae. Lee S, et al. J Nanosci Nanotechnol, 2018 Apr 1. PMID 29442983
    2. The ALD6 gene of Saccharomyces cerevisiae encodes a cytosolic, Mg(2+)-activated acetaldehyde dehydrogenase. Meaden PG, et al. Yeast, 1997 Nov. PMID 9392076
    3. Rewiring Central Carbon Metabolism Ensures Increased Provision of Acetyl-CoA and NADPH Required for 3-OH-Propionic Acid Production. Qin N, et al. ACS Synth Biol, 2020 Dec 18. PMID 33186034
    4. Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection. Butcher RA, et al. Proc Natl Acad Sci U S A, 2004 May 25. PMID 15146068, Free PMC Article
    5. Expression of aldehyde dehydrogenase 6 reduces inhibitory effect of furan derivatives on cell growth and ethanol production in Saccharomyces cerevisiae. Park SE, et al. Bioresour Technol, 2011 May. PMID 21421300

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol.
      Title: Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol.
    2. Ald6p enzymatic activity may be disadvantageous for survival under nitrogen starvation; therefore, yeast cells may preferentially eliminate Ald6p via autophagy
      Title: Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldehyde dehydrogenase [NAD(P)+] activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADPH regeneration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in acetate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ethanol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aldehyde dehydrogenase (NADP(+)) ALD6
    NP_015264.1
    • Cytosolic aldehyde dehydrogenase; activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; localizes to the mitochondrial outer surface upon oxidative stress; negative regulator of nonselective autophagy; Stb5p directly regulates the expression of ALD6 mRNA and directly binds to the ALD6 promoter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      432588..434090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183875.1 → NP_015264.1  TPA: aldehyde dehydrogenase (NADP(+)) ALD6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015264.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3V3, P54115, Q02782
      UniProtKB/TrEMBL
      A6ZWI7, B3LL07, C7GTZ5, C8ZIW9, E9P9H2, G2WPB8, N1NX93
      Conserved Domains (1) summary
      cd07091
      Location:23 → 498
      ALDH_F1-2_Ald2-like; ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54115.4

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