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    SRL4 Srl4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856074, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SRL4
    Official Full Name
    Srl4p
    Primary source
    SGD:S000005954
    Locus tag
    YPL033C
    See related
    AllianceGenome:SGD:S000005954; FungiDB:YPL033C; VEuPathDB:YPL033C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in deoxyribonucleoside triphosphate metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SRL4 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (487362..488207, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene H(+)-exporting P2-type ATPase PMA2 Neighboring gene uncharacterized protein Neighboring gene Svl3p Neighboring gene cyclin-dependent serine/threonine-protein kinase PHO85

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mutation of a novel Saccharomyces cerevisiae SRL4 gene rescues the lethality of rad53 and lcd1 mutations by modulating dNTP levels. Choi DH, et al. J Microbiol, 2008 Feb. PMID 18337697
    2. Yeast and human genes that affect the Escherichia coli SOS response. Perkins EL, et al. Proc Natl Acad Sci U S A, 1999 Mar 2. PMID 10051619, Free PMC Article
    3. Role of transcription factor Kar4 in regulating downstream events in the Saccharomyces cerevisiae pheromone response pathway. Lahav R, et al. Mol Cell Biol, 2007 Feb. PMID 17101777, Free PMC Article
    4. A screen for spore wall permeability mutants identifies a secreted protease required for proper spore wall assembly. Suda Y, et al. PLoS One, 2009 Sep 25. PMID 19779569, Free PMC Article
    5. A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast. Lam C, et al. Eukaryot Cell, 2014 Mar. PMID 24390141, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SRL4 (YPL033C) may be involved in the regulation of dNTP production by its function as a negative regulator of ribonucleotide reductase.
      Title: The mutation of a novel Saccharomyces cerevisiae SRL4 gene rescues the lethality of rad53 and lcd1 mutations by modulating dNTP levels.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in deoxyribonucleoside triphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Srl4p
    NP_015292.1
    • hypothetical protein; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      487362..488207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183847.1 → NP_015292.1  TPA: Srl4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015292.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3Y0, Q03085
      UniProtKB/TrEMBL
      A6ZWL4, B5VTC7, C8ZIZ6, G2WPE5, N1P1S9
      Conserved Domains (1) summary
      cl21454
      Location:28 → 223
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03085.1

    Gene LinkOut

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