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    BET2 Rab geranylgeranyltransferase BET2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856306, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BET2
    Official Full Name
    Rab geranylgeranyltransferase BET2
    Primary source
    SGD:S000006380
    Locus tag
    YPR176C
    See related
    AllianceGenome:SGD:S000006380; FungiDB:YPR176C; VEuPathDB:YPR176C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables Rab geranylgeranyltransferase activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein geranylgeranylation; and protein targeting to membrane. Located in cytosol. Part of Rab-protein geranylgeranyltransferase complex. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BET2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (891101..892078, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Csa1p Neighboring gene DNA polymerase epsilon noncatalytic subunit Neighboring gene U4/U6-U5 snRNP complex subunit PRP4 Neighboring gene Hda3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dependence of Ypt1 and Sec4 membrane attachment on Bet2. Rossi G, et al. Nature, 1991 May 9. PMID 1903184
    2. Characterization of yeast type-II geranylgeranyltransferase. Jiang Y, et al. Methods Enzymol, 1995. PMID 8583924
    3. BTS1 encodes a geranylgeranyl diphosphate synthase in Saccharomyces cerevisiae. Jiang Y, et al. J Biol Chem, 1995 Sep 15. PMID 7665600
    4. Characterization of new mutants in the early part of the yeast secretory pathway isolated by a [3H]mannose suicide selection. Newman AP, et al. J Cell Biol, 1987 Oct. PMID 3312234, Free PMC Article
    5. Bet2p and Mad2p are components of a prenyltransferase that adds geranylgeranyl onto Ypt1p and Sec4p. Jiang Y, et al. Nature, 1993 Nov 4. PMID 8232542

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables Rab geranylgeranyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Rab geranylgeranyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein geranylgeranyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein geranylgeranylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rab-protein geranylgeranyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rab-protein geranylgeranyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rab-protein geranylgeranyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    Rab geranylgeranyltransferase BET2
    NP_015502.1
    • Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; human homolog RABGGTB can complement yeast BET2 mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      891101..892078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184273.1 → NP_015502.1  TPA: Rab geranylgeranyltransferase BET2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015502.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4H7, P20133, P32433
      UniProtKB/TrEMBL
      A6ZX51, B3LKD6, B5VTV8, C7GP59, C8ZJK5
      Conserved Domains (1) summary
      COG5029
      Location:1 → 325
      CAL1; Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20133.3

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