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    gyrA DNA gyrase subunit A [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 887105, updated on 4-Apr-2024

    Summary

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    Gene symbol
    gyrA
    Gene description
    DNA gyrase subunit A
    Locus tag
    Rv0006
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (7302..9818)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene DNA replication/repair protein RecF Neighboring gene hypothetical protein Neighboring gene DNA gyrase subunit B Neighboring gene membrane protein Neighboring gene tRNA-Ile

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specific gyrA Gene Mutations Correlate with High Prevalence of Discordant Levofloxacin Resistance in Mycobacterium tuberculosis Isolates from Beijing, China. Huo F, et al. J Mol Diagn, 2020 Sep. PMID 32619641
    2. Fluoroquinolone resistance and mutational profile of gyrA in pulmonary MDR tuberculosis patients. Kabir S, et al. BMC Pulm Med, 2020 May 11. PMID 32393213, Free PMC Article
    3. The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA). Huang YY, et al. Nucleic Acids Res, 2006. PMID 17038336, Free PMC Article
    4. Dynamics of fluoroquinolones induced resistance in DNA gyrase of Mycobacterium tuberculosis. Pandey B, et al. J Biomol Struct Dyn, 2018 Feb. PMID 28071975
    5. Purification, crystallization and preliminary X-ray diffraction experiments on the breakage-reunion domain of the DNA gyrase from Mycobacterium tuberculosis. Piton J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Nov 1. PMID 19923746, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular Characteristic of Both Levofloxacin and Moxifloxacin Resistance in Mycobacterium tuberculosis from Individuals Diagnosed with Preextensive Drug-Resistant Tuberculosis.
      Title: Molecular Characteristic of Both Levofloxacin and Moxifloxacin Resistance in Mycobacterium tuberculosis from Individuals Diagnosed with Preextensive Drug-Resistant Tuberculosis.
    2. Specific gyrA Gene Mutations Correlate with High Prevalence of Discordant Levofloxacin Resistance in Mycobacterium tuberculosis Isolates from Beijing, China.
      Title: Specific gyrA Gene Mutations Correlate with High Prevalence of Discordant Levofloxacin Resistance in Mycobacterium tuberculosis Isolates from Beijing, China.
    3. Fluoroquinolone resistance and mutational profile of gyrA in pulmonary MDR tuberculosis patients.
      Title: Fluoroquinolone resistance and mutational profile of gyrA in pulmonary MDR tuberculosis patients.
    4. Structure-based molecular docking of complex comprised of DNA bound with Gyrase A (large subunit) and Gyrase C (small subunit) with moxifloxacin (MFX) revealed high binding affinity to wild type with considerably high Glide XP docking score of -7.88 kcal/mol
      Title: Dynamics of fluoroquinolones induced resistance in DNA gyrase of Mycobacterium tuberculosis.
    5. The double mutants GyrA(A90V) GyrB(D500N) and GyrA(A90V) GyrB(T539N) are reported to be implicated in conferring higher levels of OFX resistance.
      Title: Double Mutants in DNA Gyrase Lead to Ofloxacin Resistance in Mycobacterium tuberculosis.
    6. At a given locus, topoisomerase I and DNA gyrase were localized behind and ahead of RNAP, respectively, correlating with the twin-supercoiled domains generated. The recruitment of topoisomerases was higher at the genomic loci with higher transcriptional activity and/or at regions under high torsional stress compared to silent genomic loci
      Title: Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase.
    7. Mutations in gyrA and gyrB among fuoroquinolone- and multidrug-resistant Mycobacterium tuberculosis Isolates have been described.
      Title: Mutations in gyrA and gyrB among Fluoroquinolone- and Multidrug-Resistant Mycobacterium tuberculosis Isolates.
    8. gyrA mutations are associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis.
      Title: Frequency and geographic distribution of gyrA and gyrB mutations associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis isolates: a systematic review.
    9. First evaluation of drug-resistant Mycobacterium tuberculosis clinical isolates from Congo revealed misdetection of fluoroquinolone resistance by line probe assay due to a double substitution T80A-A90G in GyrA.
      Title: First evaluation of drug-resistant Mycobacterium tuberculosis clinical isolates from Congo revealed misdetection of fluoroquinolone resistance by line probe assay due to a double substitution T80A-A90G in GyrA.
    10. The gyrA mutations at codons 90, 91 and 94 constitute the primary mechanism of fluoroquinolone resistance in Mycobacterium tuberculosis, and mutations at codon 91 in the gyrA gene may be associated with low-level resistance to ofloxacin.
      Title: Characterization of gyrA and gyrB mutations and fluoroquinolone resistance in Mycobacterium tuberculosis clinical isolates from Hubei Province, China.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    General gene information

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    Homology

    General protein information

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    Preferred Names
    DNA gyrase subunit A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      7302..9818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_214520.1 DNA gyrase subunit A [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_214520.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      J9VB15, P71574, P97136, P9WG46, Q07702
      UniProtKB/TrEMBL
      A0A2R4IPX3, H9N0J7, H9N0L4, H9N0M3, H9N0M9
      Conserved Domains (2) summary
      sd00041
      Location:515 → 562
      GyrA-ParC_C; GyrA_CTD repeat [structural motif]
      NF038098
      Location:130 → 824
      GyrA_w_intein; intein-containing DNA gyrase subunit A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WG47.1

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