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    SHF Src homology 2 domain containing F [ Homo sapiens (human) ]

    Gene ID: 90525, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SHFprovided by HGNC
    Official Full Name
    Src homology 2 domain containing Fprovided by HGNC
    Primary source
    HGNC:HGNC:25116
    See related
    Ensembl:ENSG00000138606 MIM:617313; AllianceGenome:HGNC:25116
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in apoptotic process. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal (RPKM 4.2), ovary (RPKM 4.0) and 23 other tissues See more
    Orthologs
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    Genomic context

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    See SHF in Genome Data Viewer
    Location:
    15q21.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (45167214..45201116, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (42975223..43009099, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (45459412..45493314, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9349 Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase 1 Neighboring gene uncharacterized LOC124903480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:45459911-45460412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:45461170-45461772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:45461773-45462375 Neighboring gene uncharacterized LOC124903481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:45471346-45471852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:45475299-45475847 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:45478592-45479144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6403 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:45493041-45493550 Neighboring gene tRNA-His (anticodon GTG) 1-7 Neighboring gene tRNA-His (anticodon GTG) 1-8 Neighboring gene tRNA-His (anticodon GTG) 1-9 Neighboring gene small nucleolar RNA SNORA11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SHF confers radioresistance in colorectal cancer by the regulation of mitochondrial DNA copy number. Zhu Z, et al. Clin Exp Med, 2023 Oct. PMID 36527512
    2. SHF Acts as a Novel Tumor Suppressor in Glioblastoma Multiforme by Disrupting STAT3 Dimerization. Wang J, et al. Adv Sci (Weinh), 2022 Sep. PMID 35843865, Free PMC Article
    3. Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma. Takagi D, et al. Cancer Sci, 2013 May. PMID 23360421, Free PMC Article
    4. Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. Lindholm CK, et al. Biochem Biophys Res Commun, 2000 Nov 30. PMID 11095946
    5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SHF confers radioresistance in colorectal cancer by the regulation of mitochondrial DNA copy number.
      Title: SHF confers radioresistance in colorectal cancer by the regulation of mitochondrial DNA copy number.
    2. SHF Acts as a Novel Tumor Suppressor in Glioblastoma Multiforme by Disrupting STAT3 Dimerization.
      Title: SHF Acts as a Novel Tumor Suppressor in Glioblastoma Multiforme by Disrupting STAT3 Dimerization.
    3. Patients showing high ALK and low Shf mRNA expressions showed poor prognosis.
      Title: Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126650, MGC126652

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing adapter protein F
    Names
    CTD-2651B20.7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301168.2 → NP_001288097.2  SH2 domain-containing adapter protein F isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC051619
      Conserved Domains (1) summary
      cd10392
      Location:339 → 436
      SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

    2. NM_001301169.2 → NP_001288098.2  SH2 domain-containing adapter protein F isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC051619
      Consensus CDS
      CCDS76750.1
      UniProtKB/TrEMBL
      H0YLW6
      Related
      ENSP00000453370.1, ENST00000560540.5

    3. NM_001301170.2 → NP_001288099.2  SH2 domain-containing adapter protein F isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC051619
      Consensus CDS
      CCDS76749.1
      UniProtKB/TrEMBL
      H0YLD8
      Related
      ENSP00000453168.1, ENST00000560734.5

    4. NM_001301171.2 → NP_001288100.2  SH2 domain-containing adapter protein F isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains alternate 5' exon structure and it thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC051619
      Consensus CDS
      CCDS73721.1
      UniProtKB/TrEMBL
      B4DWP8, F8W6V4
      Related
      ENSP00000411530.2, ENST00000458022.6
      Conserved Domains (1) summary
      cd10392
      Location:137 → 234
      SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

    5. NM_001394037.1 → NP_001380966.1  SH2 domain-containing adapter protein F isoform f

      Status: VALIDATED

      Source sequence(s)
      AC051619
      Consensus CDS
      CCDS91993.1
      UniProtKB/TrEMBL
      A0A8I5QJ71
      Related
      ENSP00000508579.1, ENST00000690270.1
      Conserved Domains (1) summary
      cd10392
      Location:386 → 483
      SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

    6. NM_001394038.1 → NP_001380967.1  SH2 domain-containing adapter protein F isoform g

      Status: VALIDATED

      Source sequence(s)
      AC051619
      Consensus CDS
      CCDS91994.1
      UniProtKB/TrEMBL
      H0YLM1
      Related
      ENSP00000453260.1, ENST00000560471.5

    7. NM_001394039.1 → NP_001380968.1  SH2 domain-containing adapter protein F isoform h

      Status: VALIDATED

      Source sequence(s)
      AC051619
      Conserved Domains (1) summary
      cd10392
      Location:309 → 404
      SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

    8. NM_001394040.1 → NP_001380969.1  SH2 domain-containing adapter protein F isoform i

      Status: VALIDATED

      Source sequence(s)
      AC051619

    9. NM_001394041.1 → NP_001380970.1  SH2 domain-containing adapter protein F isoform j

      Status: VALIDATED

      Source sequence(s)
      AC051619
      UniProtKB/TrEMBL
      B3KTY1
      Conserved Domains (1) summary
      PHA03247
      Location:145 → 345
      PHA03247; large tegument protein UL36; Provisional

    10. NM_001394042.1 → NP_001380971.1  SH2 domain-containing adapter protein F isoform k

      Status: VALIDATED

      Source sequence(s)
      AC051619

    11. NM_001394043.1 → NP_001380972.1  SH2 domain-containing adapter protein F isoform l

      Status: VALIDATED

      Source sequence(s)
      AC051619

    12. NM_001394044.1 → NP_001380973.1  SH2 domain-containing adapter protein F isoform m

      Status: VALIDATED

      Source sequence(s)
      AC051619

    13. NM_001394045.1 → NP_001380974.1  SH2 domain-containing adapter protein F isoform n

      Status: VALIDATED

      Source sequence(s)
      AC051619

    14. NM_001394046.1 → NP_001380975.1  SH2 domain-containing adapter protein F isoform o

      Status: VALIDATED

      Source sequence(s)
      AC051619

    15. NM_001394047.1 → NP_001380976.1  SH2 domain-containing adapter protein F isoform p

      Status: VALIDATED

      Source sequence(s)
      AC051619

    16. NM_001394048.1 → NP_001380977.1  SH2 domain-containing adapter protein F isoform q

      Status: VALIDATED

      Source sequence(s)
      AC051619

    17. NM_138356.3 → NP_612365.3  SH2 domain-containing adapter protein F isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, and it includes an additional in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC051619
      Consensus CDS
      CCDS10120.2
      UniProtKB/Swiss-Prot
      Q7M4L6, Q96IE8
      Related
      ENSP00000290894.8, ENST00000290894.12
      Conserved Domains (2) summary
      cd10392
      Location:321 → 418
      SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
      PHA03247
      Location:145 → 317
      PHA03247; large tegument protein UL36; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      45167214..45201116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433286.1 → XP_047289242.1  SH2 domain-containing adapter protein F isoform X3

    2. XM_047433285.1 → XP_047289241.1  SH2 domain-containing adapter protein F isoform X2

    3. XM_017022710.2 → XP_016878199.1  SH2 domain-containing adapter protein F isoform X4

    4. XM_011522178.3 → XP_011520480.1  SH2 domain-containing adapter protein F isoform X5

    5. XM_047433284.1 → XP_047289240.1  SH2 domain-containing adapter protein F isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      42975223..43009099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379125.1 → XP_054235100.1  SH2 domain-containing adapter protein F isoform X3

    2. XM_054379124.1 → XP_054235099.1  SH2 domain-containing adapter protein F isoform X2

    3. XM_054379126.1 → XP_054235101.1  SH2 domain-containing adapter protein F isoform X4

    4. XM_054379127.1 → XP_054235102.1  SH2 domain-containing adapter protein F isoform X5

    5. XM_054379123.1 → XP_054235098.1  SH2 domain-containing adapter protein F isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7M4L6.2 GenPept UniProtKB/Swiss-Prot:Q7M4L6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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