DLG5 discs large MAGUK scaffold protein 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DLG5provided by HGNC
Official Full Name: discs large MAGUK scaffold protein 5provided by HGNC
Primary source: HGNC:HGNC:2904
See related: Ensembl:ENSG00000151208 MIM:604090; AllianceGenome:HGNC:2904
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PDLG; YUVOB; LP-DLG; P-DLG5
Summary: This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Expression: Broad expression in placenta (RPKM 23.0), skin (RPKM 17.3) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q22.3

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (77790791..77940736, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (78659856..78795806, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (79550549..79686513, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A double-edged sword: DLG5 in diseases.
Title: A double-edged sword: DLG5 in diseases.
The scaffolding protein DLG5 promotes glioblastoma growth by controlling Sonic Hedgehog signaling in tumor stem cells.
Title: The scaffolding protein DLG5 promotes glioblastoma growth by controlling Sonic Hedgehog signaling in tumor stem cells.
Recent Hints on the Dual Role of Discs Large MAGUK Scaffold Protein 5 in Cancers and in Hepatocellular Carcinoma.
Title: Recent Hints on the Dual Role of Discs Large MAGUK Scaffold Protein 5 in Cancers and in Hepatocellular Carcinoma.
DLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes.
Title: DLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes.
Down-regulated DLG5 expression increases the stemness of breast cancer cells by enhancing TAZ expression, contributing to TAM resistance in breast cancer.
Title: DLG5 suppresses breast cancer stem cell-like characteristics to restore tamoxifen sensitivity by inhibiting TAZ expression.
Loss of DLG5 expression promoted breast cancer progression by inactivating the Hippo signaling pathway and increasing nuclear YAP.
Title: Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.
both polymorphisms of DLG5 are correlated with inflammatory bowel disease susceptibility in an ethnic-specific manner.
Title: Meta-analysis of associations between DLG5 R30Q and P1371Q polymorphisms and susceptibility to inflammatory bowel disease.
Low expression of DLG5 is associated with Crohn's disease.
Title: Expression of DLG1 and DLG5 in the Intestinal Epithelium of Patients with CD.
Data found that Dlg5 expression was significantly lower in human hepatocellular carcinoma (HCC) tissues and indicate that Dlg5 acts as a novel regulator of invadopodium-associated invasion via Girdin and by interfering with the interaction between Girdin and Tks5, which might be important for Tks5 phosphorylation in HCC cells.
Title: Discs large homolog 5 decreases formation and function of invadopodia in human hepatocellular carcinoma via Girdin and Tks5.
G113A variant may be significantly associated with Crohn's disease risk in children and colonic involvement (Meta-Analysis)
Title: The association of DLG5 polymorphisms with inflammatory bowel disease: a meta-analysis of 25 studies.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Yuksel-Vogel-Bauer syndrome MedGen: C5882751 OMIM: 620703 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10S423 (e-PCR)
- UniSTS:147970

D10S368 (e-PCR)
- UniSTS:147971

KS619 (e-PCR)
- UniSTS:253190

RH44838 (e-PCR)
- UniSTS:7711

G07285 (e-PCR)
- UniSTS:7718

D8S2279 (e-PCR)
- UniSTS:473907

G19749 (e-PCR)
- UniSTS:43873

A001X23 (e-PCR)
- UniSTS:43874

D10S1342E (e-PCR)
- UniSTS:56214

G62769 (e-PCR)
- UniSTS:139746

SHGC-57807 (e-PCR)
- UniSTS:42990

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
enables cytoskeletal protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor complex adaptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in apical protein localization	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial tube branching involved in lung morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	NAS Non-traceable Author Statement more info	PubMed
involved_in intracellular signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric collecting duct development	IEA Inferred from Electronic Annotation more info
involved_in midbrain development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroepithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in polarized epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in protein localization to adherens junction	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in zonula adherens assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in adherens junction	NAS Non-traceable Author Statement more info	PubMed
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: disks large homolog 5

Names: discs large protein LP-DLG; discs large protein P-dlg; discs, large homolog 5; large type of P-DLG; placenta and prostate DLG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011484.1 RefSeqGene

Range

4836..140800

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004747.4 → NP_004738.3 disks large homolog 5

See identical proteins and their annotated locations for NP_004738.3

Status: REVIEWED

Source sequence(s)

AB011155, AK122931, AL391421, BC030250

Consensus CDS

CCDS7353.2

UniProtKB/Swiss-Prot

A6H8Y3, Q149N1, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM6, Q8TDM7, Q9UE73, Q9Y4E3

Related

ENSP00000361467.2, ENST00000372391.7

Conserved Domains (12) summary

cd11860
Location:1597 → 1659

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1732 → 1908

GuKc; Guanylate kinase homologues

smart00228
Location:1347 → 1429

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:702 → 771

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

COG1340
Location:295 → 587

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:722 → 790

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1740 → 1907

Guanylate_kin; Guanylate kinase

pfam04822
Location:130 → 212

Takusan; Takusan

pfam07926
Location:231 → 353

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam16610
Location:1427 → 1499

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:417 → 601

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23733
Location:310 → 449

FliJ; Flagellar FliJ protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

77790791..77940736 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047425998.1 → XP_047281954.1 disks large homolog 5 isoform X5
XM_005270276.5 → XP_005270333.1 disks large homolog 5 isoform X1

See identical proteins and their annotated locations for XP_005270333.1

Conserved Domains (12) summary

cd11860
Location:1593 → 1655

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1728 → 1904

GuKc; Guanylate kinase homologues

smart00228
Location:1343 → 1425

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:698 → 767

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

COG1340
Location:291 → 583

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:718 → 786

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1736 → 1903

Guanylate_kin; Guanylate kinase

pfam04822
Location:130 → 208

Takusan; Takusan

pfam08614
Location:151 → 345

ATG16; Autophagy protein 16 (ATG16)

pfam16610
Location:1423 → 1495

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:413 → 597

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23733
Location:306 → 445

FliJ; Flagellar FliJ protein
XM_006718056.4 → XP_006718119.1 disks large homolog 5 isoform X11

See identical proteins and their annotated locations for XP_006718119.1

UniProtKB/Swiss-Prot

Q8TDM6

Conserved Domains (11) summary

cd11860
Location:1257 → 1319

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1392 → 1568

GuKc; Guanylate kinase homologues

smart00228
Location:1007 → 1089

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:702 → 771

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

COG1340
Location:295 → 587

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:722 → 790

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1400 → 1567

Guanylate_kin; Guanylate kinase

pfam04822
Location:130 → 212

Takusan; Takusan

pfam16610
Location:1087 → 1159

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:417 → 601

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23733
Location:310 → 449

FliJ; Flagellar FliJ protein
XM_011540342.2 → XP_011538644.1 disks large homolog 5 isoform X3

See identical proteins and their annotated locations for XP_011538644.1

Conserved Domains (13) summary

cd11860
Location:1507 → 1569

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1642 → 1818

GuKc; Guanylate kinase homologues

smart00228
Location:1257 → 1339

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:612 → 681

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

COG1340
Location:205 → 497

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:632 → 700

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1650 → 1817

Guanylate_kin; Guanylate kinase

pfam04822
Location:40 → 122

Takusan; Takusan

pfam07926
Location:141 → 263

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam16610
Location:1337 → 1409

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:327 → 511

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23720
Location:138 → 236

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

cl23733
Location:220 → 359

FliJ; Flagellar FliJ protein
XM_017016914.2 → XP_016872403.1 disks large homolog 5 isoform X5

UniProtKB/Swiss-Prot

Q8TDM6

Conserved Domains (12) summary

cd11860
Location:1487 → 1549

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1622 → 1798

GuKc; Guanylate kinase homologues

smart00228
Location:1237 → 1319

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:592 → 661

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

COG1340
Location:185 → 477

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:612 → 680

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1630 → 1797

Guanylate_kin; Guanylate kinase

pfam04822
Location:20 → 102

Takusan; Takusan

pfam07926
Location:121 → 243

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam16610
Location:1317 → 1389

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:307 → 491

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23733
Location:200 → 339

FliJ; Flagellar FliJ protein
XM_011540341.4 → XP_011538643.1 disks large homolog 5 isoform X2

See identical proteins and their annotated locations for XP_011538643.1

Conserved Domains (13) summary

cd11860
Location:1538 → 1600

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1673 → 1849

GuKc; Guanylate kinase homologues

smart00228
Location:1288 → 1370

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:643 → 712

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

COG1340
Location:236 → 528

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:663 → 731

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1681 → 1848

Guanylate_kin; Guanylate kinase

pfam04822
Location:71 → 153

Takusan; Takusan

pfam07926
Location:172 → 294

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam16610
Location:1368 → 1440

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:358 → 542

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23720
Location:169 → 267

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

cl23733
Location:251 → 390

FliJ; Flagellar FliJ protein
XM_017016913.2 → XP_016872402.1 disks large homolog 5 isoform X4
XM_047426000.1 → XP_047281956.1 disks large homolog 5 isoform X7
XM_011540345.2 → XP_011538647.1 disks large homolog 5 isoform X7

See identical proteins and their annotated locations for XP_011538647.1

UniProtKB/Swiss-Prot

Q8TDM6

Conserved Domains (12) summary

cd11860
Location:1442 → 1504

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1577 → 1753

GuKc; Guanylate kinase homologues

smart00228
Location:1192 → 1274

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:547 → 616

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

COG1340
Location:140 → 432

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:567 → 635

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1585 → 1752

Guanylate_kin; Guanylate kinase

pfam04822
Location:1 → 57

Takusan; Takusan

pfam07926
Location:76 → 198

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam16610
Location:1272 → 1344

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:262 → 446

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23733
Location:155 → 294

FliJ; Flagellar FliJ protein
XM_047426001.1 → XP_047281957.1 disks large homolog 5 isoform X8
XM_011540344.3 → XP_011538646.1 disks large homolog 5 isoform X6

See identical proteins and their annotated locations for XP_011538646.1

Conserved Domains (12) summary

cd11860
Location:1485 → 1547

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1620 → 1796

GuKc; Guanylate kinase homologues

smart00228
Location:1235 → 1317

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:590 → 659

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

COG1340
Location:183 → 475

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:610 → 678

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1628 → 1795

Guanylate_kin; Guanylate kinase

pfam04822
Location:18 → 100

Takusan; Takusan

pfam07926
Location:119 → 241

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam16610
Location:1315 → 1387

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:305 → 489

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23733
Location:198 → 337

FliJ; Flagellar FliJ protein
XM_011540347.3 → XP_011538649.1 disks large homolog 5 isoform X10

See identical proteins and their annotated locations for XP_011538649.1

Conserved Domains (10) summary

cd11860
Location:1291 → 1353

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1426 → 1602

GuKc; Guanylate kinase homologues

smart00228
Location:1041 → 1123

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:396 → 465

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

COG1340
Location:27 → 281

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:416 → 484

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1434 → 1601

Guanylate_kin; Guanylate kinase

pfam16610
Location:1121 → 1193

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:111 → 295

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23733
Location:4 → 143

FliJ; Flagellar FliJ protein
XM_017016915.2 → XP_016872404.1 disks large homolog 5 isoform X10

Conserved Domains (10) summary

cd11860
Location:1291 → 1353

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1426 → 1602

GuKc; Guanylate kinase homologues

smart00228
Location:1041 → 1123

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:396 → 465

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

COG1340
Location:27 → 281

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:416 → 484

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1434 → 1601

Guanylate_kin; Guanylate kinase

pfam16610
Location:1121 → 1193

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:111 → 295

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23733
Location:4 → 143

FliJ; Flagellar FliJ protein
XM_024448250.2 → XP_024304018.1 disks large homolog 5 isoform X13

Conserved Domains (7) summary

cd11860
Location:1112 → 1174

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00072
Location:1247 → 1423

GuKc; Guanylate kinase homologues

smart00228
Location:862 → 944

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:237 → 305

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16610
Location:942 → 1014

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl26464
Location:490 → 863

Atrophin-1; Atrophin-1 family

cl26472
Location:9 → 149

DUF3084; Protein of unknown function (DUF3084)
XM_011540346.3 → XP_011538648.1 disks large homolog 5 isoform X9

See identical proteins and their annotated locations for XP_011538648.1

Conserved Domains (10) summary

cd11860
Location:1597 → 1656

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

smart00228
Location:1347 → 1429

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:702 → 771

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

COG1340
Location:295 → 587

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:722 → 790

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam04822
Location:130 → 212

Takusan; Takusan

pfam07926
Location:231 → 353

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam16610
Location:1427 → 1499

dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5

cl12013
Location:417 → 601

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23733
Location:310 → 449

FliJ; Flagellar FliJ protein
XM_047426002.1 → XP_047281958.1 disks large homolog 5 isoform X12
XM_006718057.4 → XP_006718120.1 disks large homolog 5 isoform X14

See identical proteins and their annotated locations for XP_006718120.1

Conserved Domains (6) summary

COG0265
Location:702 → 771

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

COG1340
Location:295 → 587

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00992
Location:722 → 790

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam04822
Location:130 → 212

Takusan; Takusan

cl12013
Location:417 → 601

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23733
Location:310 → 449

FliJ; Flagellar FliJ protein
XM_047426003.1 → XP_047281959.1 disks large homolog 5 isoform X15