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    ZFAND4 zinc finger AN1-type containing 4 [ Homo sapiens (human) ]

    Gene ID: 93550, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZFAND4provided by HGNC
    Official Full Name
    zinc finger AN1-type containing 4provided by HGNC
    Primary source
    HGNC:HGNC:23504
    See related
    Ensembl:ENSG00000172671 AllianceGenome:HGNC:23504
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANUBL1
    Summary
    Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 26.4), lymph node (RPKM 2.8) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZFAND4 in Genome Data Viewer
    Location:
    10q11.22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (45615500..45672813, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (46496511..46553811, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (46110948..46168261, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene arachidonate 5-lipoxygenase Neighboring gene uncharacterized LOC102724323 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:45958734-45959933 Neighboring gene uncharacterized LOC105378286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45970297-45970798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45970799-45971298 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45998823-45999323 Neighboring gene VISTA enhancer hs2065 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:46070300-46070960 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:46086550-46087050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3322 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2347 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 10, pseudogene Neighboring gene family with sequence similarity 21 member F, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma. Kurihara-Shimomura M, et al. J Clin Pathol, 2018 May. PMID 29074611
    2. MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer. Tang L, et al. Oncol Rep, 2015 Apr. PMID 25682742
    3. E3 ubiquitin ligase FBXO22 inhibits SARS-CoV-2 replication via promoting proteasome-dependent degradation of NSP5. Zhou Y, et al. J Med Virol, 2024 Sep. PMID 39223933
    4. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Grupe A, et al. Am J Hum Genet, 2006 Jan. PMID 16385451, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suggest that ZFAND4 is a useful marker for predicting metastasis and poor prognosis in patients with oral squamous cell carcinoma.
      Title: Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma.
    2. In gastric cancer cells, ANUBL1 was upregulated and promoted proliferation of SGC-7901 cells. Over-expression decreased miR-182 expression. ANUBL1 expression was in turn directly downregulated by miR-182 in a negative feedback loop.
      Title: MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40185

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AN1-type zinc finger protein 4
    Names
    AN1, ubiquitin-like, homolog
    AN1-type zinc finger and ubiquitin domain-containing protein 1
    AN1-type zinc finger and ubiquitin domain-containing protein-like 1
    zinc finger, AN1-type domain 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128324.2 → NP_001121796.1  AN1-type zinc finger protein 4 isoform a

      See identical proteins and their annotated locations for NP_001121796.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      BC045587, DB522994
      Consensus CDS
      CCDS7214.1
      UniProtKB/Swiss-Prot
      A8K8V4, B2RAX2, Q5VVY5, Q86XD8
      UniProtKB/TrEMBL
      A8K8Q5
      Conserved Domains (3) summary
      cd01802
      Location:1 → 103
      AN1_N; ubiquitin-like domain of AN1
      smart00154
      Location:667 → 705
      ZnF_AN1; AN1-like Zinc finger
      smart00213
      Location:28 → 99
      UBQ; Ubiquitin homologues

    2. NM_001282905.1 → NP_001269834.1  AN1-type zinc finger protein 4 isoform b

      See identical proteins and their annotated locations for NP_001269834.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in its 5' region and uses a downstream start codon compared to variant 1. It encodes isoform b which has a shorter N-terminus compared to isoform a. Variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AF311324, AK292420, BC048968, DB454939, DB456684, DB522994
      Consensus CDS
      CCDS60520.1
      UniProtKB/TrEMBL
      A8K8Q5, J3KPC0
      Related
      ENSP00000363486.3, ENST00000374366.7
      Conserved Domains (2) summary
      smart00154
      Location:593 → 631
      ZnF_AN1; AN1-like Zinc finger
      cl00155
      Location:1 → 29
      UBQ; Ubiquitin-like proteins

    3. NM_001282906.1 → NP_001269835.1  AN1-type zinc finger protein 4 isoform b

      See identical proteins and their annotated locations for NP_001269835.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, contains an alternate exon in its 5' region and uses a downstream start codon compared to variant 1. It encodes isoform b which has a shorter N-terminus compared to isoform a. Variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AF311324, AK292420, BC045587, DB522994
      Consensus CDS
      CCDS60520.1
      UniProtKB/TrEMBL
      A8K8Q5, J3KPC0
      Conserved Domains (2) summary
      smart00154
      Location:593 → 631
      ZnF_AN1; AN1-like Zinc finger
      cl00155
      Location:1 → 29
      UBQ; Ubiquitin-like proteins

    4. NM_174890.4 → NP_777550.2  AN1-type zinc finger protein 4 isoform a

      See identical proteins and their annotated locations for NP_777550.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AF311324, AL445201, BC048968, DB454939, DB456684, DB522994
      Consensus CDS
      CCDS7214.1
      UniProtKB/Swiss-Prot
      A8K8V4, B2RAX2, Q5VVY5, Q86XD8
      UniProtKB/TrEMBL
      A8K8Q5
      Related
      ENSP00000339484.5, ENST00000344646.10
      Conserved Domains (3) summary
      cd01802
      Location:1 → 103
      AN1_N; ubiquitin-like domain of AN1
      smart00154
      Location:667 → 705
      ZnF_AN1; AN1-like Zinc finger
      smart00213
      Location:28 → 99
      UBQ; Ubiquitin homologues

    RNA

    1. NR_104256.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses a different 5' terminal exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK292420, BC017591, BC045587, CR741609
      Related
      ENST00000465407.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      45615500..45672813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016939.3 → XP_016872428.1  AN1-type zinc finger protein 4 isoform X8

      UniProtKB/TrEMBL
      B3KUL6
      Conserved Domains (2) summary
      smart00154
      Location:619 → 657
      ZnF_AN1; AN1-like Zinc finger
      cl00155
      Location:1 → 61
      UBQ; Ubiquitin-like proteins

    2. XM_017016933.3 → XP_016872422.1  AN1-type zinc finger protein 4 isoform X5

      UniProtKB/TrEMBL
      A8K8Q5

    3. XM_047426012.1 → XP_047281968.1  AN1-type zinc finger protein 4 isoform X5

    4. XM_047426014.1 → XP_047281970.1  AN1-type zinc finger protein 4 isoform X8

    5. XM_047426011.1 → XP_047281967.1  AN1-type zinc finger protein 4 isoform X5

    6. XM_047426010.1 → XP_047281966.1  AN1-type zinc finger protein 4 isoform X5

    7. XM_011540366.3 → XP_011538668.1  AN1-type zinc finger protein 4 isoform X4

      UniProtKB/TrEMBL
      B3KUL6
      Conserved Domains (2) summary
      smart00154
      Location:675 → 713
      ZnF_AN1; AN1-like Zinc finger
      cl00155
      Location:57 → 117
      UBQ; Ubiquitin-like proteins

    8. XM_047426009.1 → XP_047281965.1  AN1-type zinc finger protein 4 isoform X2

    9. XM_047426008.1 → XP_047281964.1  AN1-type zinc finger protein 4 isoform X1

    10. XM_047426017.1 → XP_047281973.1  AN1-type zinc finger protein 4 isoform X5

    11. XM_017016931.2 → XP_016872420.1  AN1-type zinc finger protein 4 isoform X3

      UniProtKB/TrEMBL
      B3KUL6

    12. XM_047426016.1 → XP_047281972.1  AN1-type zinc finger protein 4 isoform X11

    13. XM_017016940.3 → XP_016872429.1  AN1-type zinc finger protein 4 isoform X9

      UniProtKB/TrEMBL
      A8K8Q5

    14. XM_011540368.2 → XP_011538670.1  AN1-type zinc finger protein 4 isoform X12

      UniProtKB/TrEMBL
      B3KUL6
      Conserved Domains (1) summary
      smart00154
      Location:495 → 533
      ZnF_AN1; AN1-like Zinc finger

    15. XM_047426018.1 → XP_047281974.1  AN1-type zinc finger protein 4 isoform X13

    16. XM_047426015.1 → XP_047281971.1  AN1-type zinc finger protein 4 isoform X10

    17. XM_047426013.1 → XP_047281969.1  AN1-type zinc finger protein 4 isoform X7

    18. XM_017016935.2 → XP_016872424.2  AN1-type zinc finger protein 4 isoform X6

    RNA

    1. XR_001747259.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      46496511..46553811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367182.1 → XP_054223157.1  AN1-type zinc finger protein 4 isoform X8

    2. XM_054367177.1 → XP_054223152.1  AN1-type zinc finger protein 4 isoform X5

    3. XM_054367176.1 → XP_054223151.1  AN1-type zinc finger protein 4 isoform X4

    4. XM_054367174.1 → XP_054223149.1  AN1-type zinc finger protein 4 isoform X2

    5. XM_054367173.1 → XP_054223148.1  AN1-type zinc finger protein 4 isoform X1

    6. XM_054367178.1 → XP_054223153.1  AN1-type zinc finger protein 4 isoform X5

    7. XM_054367179.1 → XP_054223154.1  AN1-type zinc finger protein 4 isoform X5

    8. XM_054367183.1 → XP_054223158.1  AN1-type zinc finger protein 4 isoform X8

    9. XM_054367187.1 → XP_054223162.1  AN1-type zinc finger protein 4 isoform X5

    10. XM_054367175.1 → XP_054223150.1  AN1-type zinc finger protein 4 isoform X3

    11. XM_054367186.1 → XP_054223161.1  AN1-type zinc finger protein 4 isoform X11

    12. XM_054367184.1 → XP_054223159.1  AN1-type zinc finger protein 4 isoform X9

    13. XM_054367188.1 → XP_054223163.1  AN1-type zinc finger protein 4 isoform X12

    14. XM_054367189.1 → XP_054223164.1  AN1-type zinc finger protein 4 isoform X13

    15. XM_054367185.1 → XP_054223160.1  AN1-type zinc finger protein 4 isoform X10

    16. XM_054367181.1 → XP_054223156.1  AN1-type zinc finger protein 4 isoform X7

    17. XM_054367180.1 → XP_054223155.1  AN1-type zinc finger protein 4 isoform X6

    RNA

    1. XR_008488312.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86XD8.2 GenPept UniProtKB/Swiss-Prot:Q86XD8

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