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    wzzE enterobacterial common antigen polysaccharide co-polymerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944815, updated on 17-Dec-2024

    Summary

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    Official Symbol
    wzzE
    Official Full Name
    enterobacterial common antigen polysaccharide co-polymerase
    Primary source
    ECOCYC:EG11295
    Locus tag
    b3785
    See related
    ASAP:ABE-0012370
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3777; wzz; yifC
    Summary
    Mutants have elevated OM vesiculation (McBroom, 2006). [More information is available at EcoGene: EG11295]. WzzE is responsible for regulating the length of phosphoglyceride-linked Enterobacterial Common Antigen (ECAPG) polysaccharide chains formed from polymerization by WzyE utilizing Lipid III in the periplasm. [More information is available at EcoCyc: EG11295].
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    Genomic context

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    Sequence:
    NC_000913.3 (3969031..3970077)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene transcription termination factor Rho Neighboring gene UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene UDP-N-acetylglucosamine 2-epimerase Neighboring gene UDP-N-acetyl-D-mannosamine dehydrogenase Neighboring gene dTDP-glucose 4,6-dehydratase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of predicted coiled-coil regions in the Escherichia coli K-12 O-antigen polysaccharide chain length determinant Wzz. Marolda CL, et al. J Bacteriol, 2008 Mar. PMID 18203821, Free PMC Article
    2. [wzzE does not affect lipopolysaccharide phenotype of avian pathogenic Escherichia coli from clinical ducking]. Zuo J, et al. Wei Sheng Wu Xue Bao, 2016 May 4. PMID 29727150
    3. Quaternary structure of WzzB and WzzE polysaccharide copolymerases. Kalynych S, et al. Protein Sci, 2015 Jan. PMID 25307743, Free PMC Article
    4. Sequence-structure relationships in polysaccharide co-polymerase (PCP) proteins. Morona R, et al. Trends Biochem Sci, 2009 Feb. PMID 19058968
    5. Bacterial polysaccharide co-polymerases share a common framework for control of polymer length. Tocilj A, et al. Nat Struct Mol Biol, 2008 Feb. PMID 18204465

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WzzE is not involved in the synthesis of lipopolysaccharide but participates in the pathogenic process.
      Title: [wzzE does not affect lipopolysaccharide phenotype of avian pathogenic Escherichia coli from clinical ducking].
    2. E.coli WzzB and WzzE Polysaccharide Copolymerases form octameric homo-oligomeric complexes.
      Title: Quaternary structure of WzzB and WzzE polysaccharide copolymerases.
    3. Results suggest that the regions predicted to be coiled coils are important for Wzz function because they maintain the native conformation of the protein, although the existence of coiled coils could not be demonstrated experimentally.
      Title: Functional analysis of predicted coiled-coil regions in the Escherichia coli K-12 O-antigen polysaccharide chain length determinant Wzz.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in enterobacterial common antigen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within enterobacterial common antigen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    enterobacterial common antigen polysaccharide co-polymerase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3969031..3970077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418232.2 enterobacterial common antigen polysaccharide co-polymerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418232.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3IUK6, A0A1X3JA10, A0A5B9AR56, A0A7H9SIT9, A0A8S7CQX5, C3SKP2, D3H3Z4
      Conserved Domains (1) summary
      PRK11638
      Location:8 → 348
      PRK11638; ECA polysaccharide chain length modulation protein
    Nucleotide Protein
    Heading Accession and Version

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