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    ycaC putative hydrolase YcaC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945512, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ycaC
    Official Full Name
    putative hydrolase YcaC
    Primary source
    ECOCYC:EG11241
    Locus tag
    b0897
    See related
    ASAP:ABE-0003050
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0888
    Summary
    Leu-155 is a Met-155 in the crystallized protein, a commercial GAD prep from Worthington. [More information is available at EcoGene: EG11241]. The crystal structure of YcaC, solved at 1.8 resolution, indicates that YcaC has similarity to hydrolases and forms a homooctamer (a dimer of tetrameric ring structures) . [More information is available at EcoCyc: EG11241].
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    Genomic context

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    Sequence:
    NC_000913.3 (944931..945557, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene dimethyl sulfoxide reductase subunit B Neighboring gene dimethyl sulfoxide reductase subunit C Neighboring gene putative transporter YcaD Neighboring gene putative transporter YcaM

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ycaC-related protein from the amphioxus Branchiostoma belcheri (BbycaCR) interacts with creatine kinase. Jiang S, et al. FEBS J, 2008 Sep. PMID 18699781
    2. Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii. Du X, et al. Biochemistry, 2001 Nov 27. PMID 11714269
    3. Energetics-based protein profiling on a proteomic scale: identification of proteins resistant to proteolysis. Park C, et al. J Mol Biol, 2007 May 18. PMID 17400245, Free PMC Article
    4. The Crl-RpoS regulon of Escherichia coli. Lelong C, et al. Mol Cell Proteomics, 2007 Apr. PMID 17224607
    5. A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Lasserre JP, et al. Electrophoresis, 2006 Aug. PMID 16858726

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: The 1.8 A crystal structure of the ycaC gene product from Escherichia coli reveals an octameric hydrolase of unknown specificity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    putative hydrolase YcaC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      944931..945557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415417.1 putative hydrolase YcaC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415417.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376W0W6, A0A5B9AL78
      Conserved Domains (1) summary
      cd01012
      Location:14 → 174
      YcaC_related; YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. ...
    Nucleotide Protein
    Heading Accession and Version

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