U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    radD putative DNA repair helicase RadD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945529, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    radD
    Official Full Name
    putative DNA repair helicase RadD
    Primary source
    ECOCYC:EG12045
    Locus tag
    b2184
    See related
    ASAP:ABE-0007228
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2178; yejH; yejI; yejJ
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2280632..2282392)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump Bcr Neighboring gene 16S rRNA pseudouridine(516) synthase Neighboring gene 50S ribosomal subunit protein L25 Neighboring gene nucleoid-associated protein YejK

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Interaction with single-stranded DNA-binding protein modulates Escherichia coli RadD DNA repair activities. Osorio Garcia MA, et al. J Biol Chem, 2023 Jun. PMID 37142225, Free PMC Article
    2. Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from Escherichia coli. Tian LF, et al. Int J Mol Sci, 2023 Jan 1. PMID 36614183, Free PMC Article
    3. Crystal structure of a novel ATPase RadD from Escherichia coli. Kuang X, et al. Proteins, 2019 Sep. PMID 31035307
    4. Escherichia coli radD (yejH) gene: a novel function involved in radiation resistance and double-strand break repair. Chen SH, et al. Mol Microbiol, 2015 Mar. PMID 25425430, Free PMC Article
    5. Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins. Romero ZJ, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31665437, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction with single-stranded DNA-binding protein modulates Escherichia coli RadD DNA repair activities.
      Title: Interaction with single-stranded DNA-binding protein modulates Escherichia coli RadD DNA repair activities.
    2. Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from Escherichia coli.
      Title: Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from Escherichia coli.
    3. Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD.
      Title: Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD.
    4. RadD protein suppresses crossovers, and Uup prevents nucleoid mis-segregation during Dna replication of defective DNA sequences.
      Title: Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins.
    5. it is likely that the repair function of RadD is mediated through interaction with SSB at the site of damage.
      Title: Escherichia coli RadD Protein Functionally Interacts with the Single-stranded DNA-binding Protein.
    6. investigation of the function of yejH; established a role for yejH gene product in repair of double-strand breaks that largely overlaps that of the genes radA and recG; propose yejH be renamed radD, reflecting its role in DNA repair of radiation damage
      Title: Escherichia coli radD (yejH) gene: a novel function involved in radiation resistance and double-strand break repair.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within double-strand break repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within postreplication repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative DNA repair helicase RadD

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2280632..2282392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416689.1 putative DNA repair helicase RadD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416689.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FWJ3
      Conserved Domains (2) summary
      COG1061
      Location:1 → 364
      SSL2; Superfamily II DNA or RNA helicase [Transcription, Replication, recombination and repair]
      cl00671
      Location:428 → 451
      Ribosomal_L40e; Ribosomal L40e family
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.